In this article, we present an integrated broadband complementary metal-oxide semiconductor single-chip transceiver suitable for the realization of multi-nuclear pulsed nuclear magnetic resonance (NMR) probes. The realized single-chip transceiver can be interfaced with on-chip integrated microcoils or external LC resonators operating in the range from 1 MHz to 1 GHz. The dimension of the chip is about 1 mm2. It consists of a radio-frequency (RF) power amplifier, a low-noise RF preamplifier, a frequency mixer, an audio-frequency amplifier, and fully integrated transmit-receive switches. As specific example, we show its use for multi-nuclear NMR spectroscopy. With an integrated coil of about 150 μm external diameter, a 1H spin sensitivity of about 1.5 × 1013 spins/Hz1/2 is achieved at 7 T.

1.
P. T.
Callaghan
,
Principles of Nuclear Magnetic Resonance Microscopy
(
Clarendon Press
,
Oxford
,
1991
).
2.
A.
Abragam
,
The Principles of Nuclear Magnetic Resonance
(
Clarendon Press
,
Oxford
,
1961
).
4.
R.
Haken
and
B.
Blumich
,
J. Magn. Reson.
144
(
2
),
195
(
2000
).
5.
H.
Lee
,
E.
Sun
,
D.
Ham
, and
R.
Weissleder
,
Nat. Med.
14
(
8
),
869
(
2008
).
6.
K. M.
Lei
,
P. I.
Mak
,
M. K.
Law
, and
R. P.
Martins
,
Analyst
139
(
23
),
6204
(
2014
).
7.
H.
Kuhn
,
M.
Klein
,
A.
Wiesmath
,
D. E.
Demco
,
B.
Blumich
,
J.
Kelm
, and
P. W.
Gold
,
Magn. Reson. Imaging
19
(
3-4
),
497
(
2001
).
8.
R.
Sacchi
,
F.
Addeo
, and
L.
Paolillo
,
Magn. Reson. Chem.
35
,
S133
(
1997
).
9.
See http://picospin.com/ for bench-top NMR spectrometers.
10.
See http://www.nmr-mouse.de/ for NMR-MOUSE systems.
11.
P. J.
Mohr
,
B. N.
Taylor
, and
D. B.
Newell
,
J. Phys. Chem. Ref. Data
41
(
4
),
043109
(
2012
).
12.
D. I.
Hoult
and
R. E.
Richards
,
J. Magn. Reson.
24
(
1
),
71
(
1976
).
13.
H. S.
Gutowsky
,
L. H.
Meyer
, and
R. E.
McClure
,
Rev. Sci. Instrum.
24
(
8
),
644
(
1953
).
14.
K.
Halbach
,
Nucl. Instrum. Methods
169
(
1
),
1
(
1980
).
15.
E.
Danieli
,
J.
Perlo
,
B.
Blumich
, and
F.
Casanova
,
Angew. Chem., Int. Ed.
49
(
24
),
4133
(
2010
).
16.
N.
Sun
,
T. J.
Yoon
,
H.
Lee
,
W.
Andress
,
R.
Weissleder
, and
D.
Ham
,
IEEE J. Solid-State Circuits
46
(
1
),
342
(
2011
).
17.
D.
Ha
,
J.
Paulsen
,
N.
Sun
,
Y.-Q.
Song
, and
D.
Ham
,
Proceedings of the National Academy of Sciences
111
,
11955
(
2014
).
18.
J.
Kim
,
B.
Hammer
, and
R.
Harjani
,
2012 IEEE Custom Integrated Circuits Conference (CICC)
2012
.
19.
N.
Sun
,
Y.
Liu
,
H.
Lee
,
R.
Weissleder
, and
D.
Ham
,
IEEE J. Solid-State Circuits
44
(
5
),
1629
(
2009
).
20.
J.
Anders
,
G.
Chiaramonte
,
P.
SanGiorgio
, and
G.
Boero
,
J. Magn. Reson.
201
(
2
),
239
(
2009
).
21.
T.
Cherifi
,
N.
Abouchi
,
G. N.
Lu
,
L.
Bouchet-Fakri
,
L.
Quiquerez
,
B.
Sorli
,
J. F.
Chateaux
,
M.
Pitaval
, and
P.
Morin
,
IEEE Trans. Circuits Syst. I: Regular Pap.
52
(
12
),
2576
(
2005
).
22.
J.
Anders
,
P.
SanGiorgio
,
X.
Deligianni
,
F.
Santini
,
K.
Scheffler
, and
G.
Boero
,
Magn. Reson. Med.
67
(
1
),
290
(
2012
).
23.
J.
Anders
,
P.
SanGiorgio
, and
G.
Boero
,
J. Magn. Reson.
209
(
1
),
1
(
2011
).
24.
G.
Boero
,
J.
Frounchi
,
B.
Furrer
,
P. A.
Besse
, and
R. S.
Popovic
,
Rev. Sci. Instrum.
72
(
6
),
2764
(
2001
).
25.
R. M.
Fratila
,
M. V.
Gomez
,
S.
Sykora
, and
A. H.
Velders
,
Nat. Commun.
5
,
3025
(
2014
).
26.
D. L.
Olson
,
T. L.
Peck
,
A. G.
Webb
,
R. L.
Magin
, and
J. V.
Sweedler
,
Science
270
(
5244
),
1967
(
1995
).
27.
See supplementary material at http://dx.doi.org/10.1063/1.4916206 for details on electronics.
28.
T. H.
Lee
,
The Design of CMOS Radio-Frequency Integrated Circuits
(
Cambridge university press
,
2004
).
29.
W. G.
Proctor
and
F. C.
Yu
,
Phys. Rev.
77
(
5
),
717
(
1950
).
30.
E. L.
Hahn
,
Phys. Rev.
80
(
4
),
580
(
1950
).
31.
N.
Bloembergen
,
E. M.
Purcell
, and
R. V.
Pound
,
Phys. Rev.
73
(
7
),
679
(
1948
).
32.
K.
Kuhlmann
and
D. M.
Grant
,
J. Phys. Chem.
68
(
11
),
3208
(
1964
).
33.
R. K.
Harris
,
E. D.
Becker
,
S. M. C.
Menezes
,
P.
Granger
,
R. E.
Hoffman
, and
K. W.
Zilm
,
Pure Appl. Chem.
80
(
1
),
59
(
2008
).
34.
H.
Sato
and
Y.
Tanaka
,
J. Polym. Sci., Part A: Polym. Chem.
17
(
11
),
3551
(
1979
).

Supplementary Material

You do not currently have access to this content.