Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and ) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.
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September 2009
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September 10 2009
Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation Available to Purchase
Hyun-Jung Lim;
Hyun-Jung Lim
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
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Jeong-Hun Nam;
Jeong-Hun Nam
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
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Yong-Jin Lee;
Yong-Jin Lee
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
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Sehyun Shin
Sehyun Shin
a)
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
Search for other works by this author on:
Hyun-Jung Lim
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
Jeong-Hun Nam
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
Yong-Jin Lee
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
Sehyun Shin
a)
School of Mechanical Engineering,
Korea University
, Seoul 136-713, Republic of Korea
a)
Electronic mail: [email protected].
Rev. Sci. Instrum. 80, 096101 (2009)
Article history
Received:
April 22 2009
Accepted:
August 01 2009
Citation
Hyun-Jung Lim, Jeong-Hun Nam, Yong-Jin Lee, Sehyun Shin; Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation. Rev. Sci. Instrum. 1 September 2009; 80 (9): 096101. https://doi.org/10.1063/1.3223534
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