An electrochemical robotic system using standard microtiter plates as reaction wells for potentiostatic and galvanostatic electrosynthesis and high-throughput electroanalysis was conceived and realized using stepmotor driven positioning stages in combination with a flexible software. Electrode bundles specifically adapted to the experimental needs are accurately positioned in the wells of a microtiter plate followed by the automatic performance of sequences of electrosynthetic or electroanalytical techniques. The system allows us to work under inert-gas atmosphere, in aqueous and organic solvents, and to add or remove solutions by means of integrated syringe pumps. A specifically developed script language permits the user to perform very complex experimental sequences in the different wells of the microtiter plate. The hardware and software features of the developed electrochemical robotic system, the design of suitable electrode arrangements for electrosynthesis and electroanalytical techniques, as well as the reproducibility in aqueous and organic electrolytes are described. The performance of the system is demonstrated by redox screening of a Ru-complex library and by electrosynthesis with in situ analysis of a compound library.
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June 2005
Research Article|
May 17 2005
Combinatorial microelectrochemistry: Development and evaluation of an electrochemical robotic system Available to Purchase
Thomas Erichsen;
Thomas Erichsen
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
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Sabine Reiter;
Sabine Reiter
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
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Victoria Ryabova;
Victoria Ryabova
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
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Eva Maria Bonsen;
Eva Maria Bonsen
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
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Wolfgang Schuhmann;
Wolfgang Schuhmann
a)
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
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Wolfgang Märkle;
Wolfgang Märkle
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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Carsten Tittel;
Carsten Tittel
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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Günther Jung;
Günther Jung
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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Bernd Speiser
Bernd Speiser
b)
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
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Thomas Erichsen
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
Sabine Reiter
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
Victoria Ryabova
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
Eva Maria Bonsen
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
Wolfgang Schuhmann
a)
Anal. Chem.—Elektroanalytik & Sensorik,
Ruhr-Universität Bochum
, Universitätsstrasse 150, D-44780 Bochum, Germany
Wolfgang Märkle
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
Carsten Tittel
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
Günther Jung
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germany
Bernd Speiser
b)
Institut für Organische Chemie,
Universität Tübingen
, Auf der Morgenstelle 18, D-72076 Tübingen, Germanya)
Author to whom correspondence should be addressed; electronic mail: [email protected]
b)
Electronic mail: [email protected]
Rev. Sci. Instrum. 76, 062204 (2005)
Article history
Received:
November 01 2004
Accepted:
February 21 2005
Citation
Thomas Erichsen, Sabine Reiter, Victoria Ryabova, Eva Maria Bonsen, Wolfgang Schuhmann, Wolfgang Märkle, Carsten Tittel, Günther Jung, Bernd Speiser; Combinatorial microelectrochemistry: Development and evaluation of an electrochemical robotic system. Rev. Sci. Instrum. 1 June 2005; 76 (6): 062204. https://doi.org/10.1063/1.1906106
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