We show that cryogenically cooled, photon counting superconducting tunnel junctions (STJs) can be used to simultaneously record the optical spectra from multiple biological fluorochromes. Measurements with a single-pixel tantalum STJ with a wavelength resolving power of about 10 confirm the expected sensitivity advantage with respect to the photomultiplier-based detectors commonly used to record signals from microarrays and other fluorescent biological systems.
Detection of multiple fluorescent labels using superconducting tunnel junction detectors
G. W. Fraser, J. S. Heslop-Harrison, T. Schwarzacher, A. D. Holland, P. Verhoeve, A. Peacock; Detection of multiple fluorescent labels using superconducting tunnel junction detectors. Rev. Sci. Instrum. 1 September 2003; 74 (9): 4140–4144. https://doi.org/10.1063/1.1599059
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