A combined photothermal-refractometric detector for high-performance liquid chromatography is proposed. Five metal complexes as 4-pyridylazo-2-naphthol chelates and three sugars were investigated as model substances. For these compounds, detection limits, repeatability, and reproducibility of determination were calculated. Obtained results were compared with results for traditional detectors, which show that photothermal detection has higher sensitivity than photometric and other absorption detectors.

Topics
Photothermal detection, Interferometry, Photometry, Thermo optic effects, Liquid chromatography
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