Glioblastoma is one of the most aggressive brain cancers. Chemotherapy is a standard modality for its therapy. Here, we demonstrated a novel strategy using a helium gas discharge tube as a tunable electromagnetic emission source to sensitize glioblastoma cells to the cytotoxicity of temozolomide (TMZ), a widely used drug for glioblastoma. After a single 7-min of treatment, the efficacy of TMZ was enhanced in two typical glioblastoma cell lines U87MG and A172 without affecting a normal human astrocyte cell line hTERT/E6/E7. The discharge tube is a non-invasive approach, which provides a safe, controllable, stable, and low-cost modality to improve the conventional chemotherapy.
Sensitization of glioblastoma cells to temozolomide by a helium gas discharge tube
Xiaoliang Yao, Li Lin, Vikas Soni, Eda Gjika, Jonathan H. Sherman, Dayun Yan, Michael Keidar; Sensitization of glioblastoma cells to temozolomide by a helium gas discharge tube. Phys. Plasmas 1 November 2020; 27 (11): 114502. https://doi.org/10.1063/5.0017913
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