In microfluidic systems, droplets undergo intricate deformations as they traverse flow-focusing junctions, posing a challenging task for accurate measurement, especially during short transit times. This study investigates the physical behavior of droplets within dense emulsions in diverse microchannel geometries, specifically focusing on the impact of varying opening angles within the primary channel and injection rates of fluid components. Employing a sophisticated droplet tracking tool based on deep-learning techniques, we analyze multiple frames from flow-focusing experiments to quantitatively characterize droplet deformation in terms of ratio between maximum width and height and propensity to form liquid with hexagonal spatial arrangement. Our findings reveal the existence of an optimal opening angle where shape deformations are minimal and hexagonal arrangement is maximal. Variations of fluid injection rates are also found to affect size and packing fraction of the emulsion in the exit channel. This paper offers insight into deformations, size, and structure of fluid emulsions relative to microchannel geometry and other flow-related parameters captured through machine learning, with potential implications for the design of microchips utilized in cellular transport and tissue engineering applications.
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February 2024
Research Article|
February 06 2024
Measuring arrangement and size distributions of flowing droplets in microchannels through deep learning using DropTrack
Special Collection:
Microscopic Channel Flows
Mihir Durve
;
Mihir Durve
(Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing)
1
Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT)
, viale Regina Elena 295, Rome 00161, Italy
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Sibilla Orsini;
Sibilla Orsini
(Conceptualization, Data curation, Methodology, Writing – original draft, Writing – review & editing)
2
NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore
, Piazza San Silvestro 12, Pisa 56127, Italy
3
Istituto per le Applicazioni del Calcolo del Consiglio Nazionale delle Ricerche
, via dei Taurini 19, Roma 00185, Italy
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Adriano Tiribocchi
;
Adriano Tiribocchi
(Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing)
3
Istituto per le Applicazioni del Calcolo del Consiglio Nazionale delle Ricerche
, via dei Taurini 19, Roma 00185, Italy
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Andrea Montessori
;
Andrea Montessori
(Conceptualization, Software, Writing – review & editing)
4
Dipartimento di Ingegneria, Università degli Studi Roma tre
, via Vito Volterra 62, Rome 00146, Italy
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Jean-Michel Tucny
;
Jean-Michel Tucny
(Conceptualization, Writing – original draft, Writing – review & editing)
1
Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT)
, viale Regina Elena 295, Rome 00161, Italy
4
Dipartimento di Ingegneria, Università degli Studi Roma tre
, via Vito Volterra 62, Rome 00146, Italy
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Marco Lauricella
;
Marco Lauricella
a)
(Conceptualization, Formal analysis, Methodology, Resources, Software, Supervision, Visualization, Writing – review & editing)
3
Istituto per le Applicazioni del Calcolo del Consiglio Nazionale delle Ricerche
, via dei Taurini 19, Roma 00185, Italy
a)Author to whom correspondence should be addressed: m.lauricella@cnr.it
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Andrea Camposeo
;
Andrea Camposeo
(Conceptualization, Data curation, Methodology, Supervision, Writing – original draft, Writing – review & editing)
2
NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore
, Piazza San Silvestro 12, Pisa 56127, Italy
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Dario Pisignano
;
Dario Pisignano
(Funding acquisition, Supervision, Writing – review & editing)
2
NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore
, Piazza San Silvestro 12, Pisa 56127, Italy
5
Dipartimento di Fisica, Università di Pisa
, Largo B. Pontecorvo 3, Pisa 56127, Italy
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Sauro Succi
Sauro Succi
(Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing)
1
Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT)
, viale Regina Elena 295, Rome 00161, Italy
6
Department of Physics, Harvard University
, 17 Oxford St., Cambridge, Massachusetts 02138, USA
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a)Author to whom correspondence should be addressed: m.lauricella@cnr.it
Physics of Fluids 36, 022105 (2024)
Article history
Received:
October 30 2023
Accepted:
January 09 2024
Citation
Mihir Durve, Sibilla Orsini, Adriano Tiribocchi, Andrea Montessori, Jean-Michel Tucny, Marco Lauricella, Andrea Camposeo, Dario Pisignano, Sauro Succi; Measuring arrangement and size distributions of flowing droplets in microchannels through deep learning using DropTrack. Physics of Fluids 1 February 2024; 36 (2): 022105. https://doi.org/10.1063/5.0185350
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