Modeling techniques are an essential complement to clinical studies of the retina, as they provide access to non-measurable parameters throughout the network and enable the simulation of controlled disturbances or pathologies. In this work, we propose the development of a patient-specific one-dimensional model of the arterial circulation in the retina. Our model is based on conservation laws and utilizes morphometric and velocimetric data obtained through clinical multimodal imaging to construct the network topology and impose realistic boundary conditions. Specifically, our model simulates blood flow from the central retina artery to the terminal smallest arterioles. To validate our model, we perform a sensitivity analysis and compare its results to published data. Finally, we use our model to investigate the hemodynamic consequences of focal stenosis on retinal arteries. Overall, our model provides a valuable tool for exploring the complex dynamics of retinal blood flow and their potential clinical implications.
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2023
Author(s)
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