The vitreous undergoes physical and biochemical changes with age. The most important of such degenerative changes is vitreous liquefaction or synchysis, in which pockets of liquid known as lacunae form in the vitreous gel. The movement mechanism and characteristics of vitreous liquefaction are quite complex. In this study, the flow dynamics of partial vitreous liquefaction (PVL) as two-phase viscoelastic-Newtonian fluid flow are investigated in the human eye. A reliable three-dimensional (3D) numerical procedure is developed for capturing the interface effects and dynamic characteristics of these two-phase complex fluid flows. In the present work, two different configurations of the PVL including liquefied pocket in the central and the posterior portions of the vitreous cavity are considered. The effects of lens indentation on the flow field and interface deformation of PVL inside the vitreous cavity are investigated. The results show that the curvature of the vitreous cavity due to the lens capsule increases shear and normal stresses in comparison with those for the PVL in a sphere as a simplified model. It is observed that the presence of lens indentation and the location of liquefied region are two factors that can produce conditions of asymmetry inside the vitreous body. In a realistic model of vitreous cavity, although the velocity magnitude inside the liquefied vitreous region increases when the liquefied pocket is in the posterior portion of the vitreous cavity, the stress values and the asymmetric condition of flow field become more significant for the liquefied pocket located close to the posterior lens curvature.
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