The number of patients with neurodegenerative disorders is growing rapidly, and it poses a major concern to discover effective therapies. The well-known deep brain stimulation as a treatment for Parkinson's disease has irredeemable impact on the brain tissue. Magnetothermal stimulation is a good alternative though, it is still invasive due to stereotactic injection for nanoparticle delivery. A good solution to this issue is to take advantage of microvasculature and excite the nanoparticles inside the brain capillaries. Hence, transport and dynamic analysis of blood flow through a brain capillary is crucial. This article presents a two-dimensional theoretical study of a blood flow with magnetic nanoparticles through a capillary when exposed to an alternating magnetic field. The magnetic nanoparticles are localized within the domain over time. The particle transport impacts and the dynamic interactions with the blood flow are elaborately investigated.
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August 2021
Research Article|
August 12 2021
Transport and dynamic analysis of magnetic nanoparticles in brain microvascular vessels
Special Collection:
Tribute to Frank M. White on his 88th Anniversary
Erfan Kosari
;
Erfan Kosari
Mechanical Engineering Department, University of California
, A363 Bourns Hall, Riverside, California 92521-0425, USA
Search for other works by this author on:
Kambiz Vafai
Kambiz Vafai
a)
Mechanical Engineering Department, University of California
, A363 Bourns Hall, Riverside, California 92521-0425, USA
a)Author to whom correspondence should be addressed: [email protected]
Search for other works by this author on:
Erfan Kosari
Kambiz Vafai
a)
Mechanical Engineering Department, University of California
, A363 Bourns Hall, Riverside, California 92521-0425, USA
a)Author to whom correspondence should be addressed: [email protected]
Note: This paper is part of the special topic, Tribute to Frank M. White on his 88th Anniversary.
Physics of Fluids 33, 081907 (2021)
Article history
Received:
June 23 2021
Accepted:
July 26 2021
Citation
Erfan Kosari, Kambiz Vafai; Transport and dynamic analysis of magnetic nanoparticles in brain microvascular vessels. Physics of Fluids 1 August 2021; 33 (8): 081907. https://doi.org/10.1063/5.0060860
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