A conventional invasive catheterization procedure is currently used to detect atherosclerotic severity in coronary arteries. However, it is still challenging to measure multiple consecutive stenoses (MCS) in coronary main arteries, a severe condition, by using the invasive method. In this paper, we report important hemodynamic properties such as wall shear stress (WSS) and velocity magnitude (VM) across different luminal areas of coronary stenosis in patient-based right coronary artery models of MCS using pulsatile heart flow simulations. The hemodynamic factors in coronary blood flow simulations of different degrees of stenosis indicated a relationship between the proximal moderate stenosis and distal severe stenosis models. The results show the physical effects of different hemodynamic factors including VM, mean arterial pressure difference, WSS, and virtual fractional flow reserve (vFFR), which allow for predicting the physiological computation in the MCS artery severity conditions. This study identifies the fundamental physics of coronary plaque with MCS and indicates the impact of these factors on vFFR measurements. These findings provide insights into and improvement of the pathophysiological assessment of MCS. The results reveal hemodynamic properties, which can be used to diagnose coronary irregularities using a visualization method.
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The impact of hemodynamic factors in a coronary main artery to detect the atherosclerotic severity: Single and multiple sequential stenosis cases
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March 2021
Research Article|
March 04 2021
The impact of hemodynamic factors in a coronary main artery to detect the atherosclerotic severity: Single and multiple sequential stenosis cases
K. E. Hoque
;
K. E. Hoque
1
Research Group of Fluid Flow Modeling and Simulation, Department of Applied Mathematics, University of Dhaka
, Dhaka-1000, Bangladesh
2
Department of Arts and Sciences, Faculty of Engineering, Ahsanullah University of Science and Technology
, Dhaka-1208, Bangladesh
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M. Ferdows
;
M. Ferdows
a)
1
Research Group of Fluid Flow Modeling and Simulation, Department of Applied Mathematics, University of Dhaka
, Dhaka-1000, Bangladesh
a)Author to whom correspondence should be addressed: ferdows@du.ac.bd
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S. Sawall;
S. Sawall
3
X-Ray Imaging and Computed Tomography, German Cancer Research Center
, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
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E. E. Tzirtzilakis;
E. E. Tzirtzilakis
4
Fluid Dynamics & Turbo-machinery Laboratory, Department of Mechanical Engineering, University of the Peloponnese
, Patras, Greece
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M. A. Xenos
M. A. Xenos
5
Department of Mathematics, Section of Applied Mathematics and Engineering Research, University of Ioannina
, Ioannina 45110, Greece
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a)Author to whom correspondence should be addressed: ferdows@du.ac.bd
Physics of Fluids 33, 031903 (2021)
Article history
Received:
December 25 2020
Accepted:
February 02 2021
Citation
K. E. Hoque, M. Ferdows, S. Sawall, E. E. Tzirtzilakis, M. A. Xenos; The impact of hemodynamic factors in a coronary main artery to detect the atherosclerotic severity: Single and multiple sequential stenosis cases. Physics of Fluids 1 March 2021; 33 (3): 031903. https://doi.org/10.1063/5.0041335
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