Single metallic particles and dimers of nanospheres have been used extensively for sensing, but dimers of particles provide attractive advantages because they exhibit multiple modes that can be tuned by the dimer geometry. Here, we employ correlative microscopy of single self-assembled dimers of gold nanorods to study their performance as refractometric sensors. The correlation between atomic force microscopy and single-particle white-light spectroscopy allows us to relate the measured sensitivity to numerical simulations taking into account the exact geometry of the construct. The sensitivity of the antibonding mode is in good agreement with simulations, whereas the bonding mode exhibits a reduced sensitivity related to the accessibility of the gap region between the particles. We find that the figure of merit is a trade-off between the resonance linewidth and its refractive index sensitivity, which depend in opposite ways on the interparticle angle. The presence of two narrow plasmon resonances in the visible to near-infrared wavelength regime makes nanorod dimers exciting candidates for multicolor and multiplexed sensing.
REFERENCES
1.
K. A.
Willets
and R. P.
van Duyne
, “Localized surface plasmon resonance spectroscopy and sensing
,” Annu. Rev. Phys. Chem.
58
, 267
–297
(2007
).2.
A. B.
Taylor
and P.
Zijlstra
, “Single-molecule plasmon sensing: Current status and future prospects
,” ACS Sens.
2
, 1103
–1122
(2017
).3.
J. P.
Kottmann
, O. J. F.
Martin
, D. R.
Smith
, and S.
Schultz
, “Non-regularly shaped plasmon resonant nanoparticle as localized light source for near-field microscopy
,” J. Microsc.
202
, 60
–65
(2001
).4.
G. J.
Nusz
, A. C.
Curry
, S. M.
Marinakos
, A.
Wax
, and A.
Chilkoti
, “Rational selection of gold nanorod geometry for label-free plasmonic biosensors
,” ACS Nano
3
, 795
–806
(2009
).5.
E. W. A.
Visser
, M.
Horáček
, and P.
Zijlstra
, “Plasmon rulers as a probe for real-time microsecond conformational dynamics of single molecules
,” Nano Lett.
18
, 7927
–7934
(2018
).6.
C.
Lambertz
et al, “Single particle plasmon sensors as label-free technique to monitor MinDE protein wave propagation on membranes
,” Nano Lett.
16
, 3540
–3544
(2016
).7.
M. A.
Beuwer
, M. W. J.
Prins
, and P.
Zijlstra
, “Stochastic protein interactions monitored by hundreds of single-molecule plasmonic biosensors
,” Nano Lett.
15
, 3507
–3511
(2015
).8.
I.
Ament
, J.
Prasad
, A.
Henkel
, S.
Schmachtel
, and C.
Sönnichsen
, “Single unlabeled protein detection on individual plasmonic nanoparticles
,” Nano Lett.
12
, 1092
–1095
(2012
).9.
J.
Becker
, A.
Trügler
, A.
Jakab
, U.
Hohenester
, and C.
Sönnichsen
, “The optimal aspect ratio of gold nanorods for plasmonic bio-sensing
,” Plasmonics
5
, 161
–167
(2010
).10.
H.
Chen
, X.
Kou
, Z.
Yang
, W.
Ni
, and J.
Wang
, “Shape- and size-dependent refractive index sensitivity of gold nanoparticles
,” Langmuir
24
, 5233
–5237
(2008
).11.
M. A.
Beuwer
, B.
van Hoof
, and P.
Zijlstra
, “Spatially resolved sensitivity of single-particle plasmon sensors
,” J. Phys. Chem. C
122
, 4615
–4621
(2018
).12.
E.
Prodan
, C. J.
Radloff
, N. J.
Halas
, P.
Nordlander
, and P.
Norlander
, “A hybridization model for the plasmon response of complex nanostructures
,” Science
302
, 419
–422
(2003
).13.
P.
Nordlander
, C.
Oubre
, E.
Prodan
, K.
Li
, and M. I.
Stockman
, “Plasmon hybridization in nanoparticle dimers
,” Nano Lett.
4
, 899
–903
(2004
).14.
J. I. L.
Chen
, Y.
Chen
, and D. S.
Ginger
, “Plasmonic nanoparticle dimers for optical sensing of DNA in complex media
,” J. Am. Chem. Soc.
132
, 9600
–9601
(2010
).15.
J. H.
Yoon
, F.
Selbach
, L.
Schumacher
, J.
Jose
, and S.
Schlücker
, “Surface plasmon coupling in dimers of gold nanoparticles: Experiment and theory for ideal (spherical) and nonideal (faceted) building blocks
,” ACS Photonics
6
, 642
–648
(2019
).16.
T.-J.
Yim
, Y.
Wang
, and X.
Zhang
, “Synthesis of a gold nanoparticle dimer plasmonic resonator through two-phase-mediated functionalization
,” Nanotechnology
19
, 435605
(2008
).17.
P. K.
Jain
and M. A.
El-Sayed
, “Universal scaling of plasmon coupling in metal nanostructures: Extension from particle pairs to nanoshells
,” Nano Lett.
7
, 2854
–2858
(2007
).18.
C.
Sönnichsen
, B. M.
Reinhard
, J.
Liphardt
, and A. P.
Alivisatos
, “A molecular ruler based on plasmon coupling of single gold and silver nanoparticles
,” Nat. Biotechnol.
23
, 741
–745
(2005
).19.
B. M.
Reinhard
, M.
Siu
, H.
Agarwal
, A. P.
Alivisatos
, and J.
Liphardt
, “Calibration of dynamic molecular rulers based on plasmon coupling between gold nanoparticles
,” Nano Lett.
5
, 2246
–2252
(2005
).20.
C.
Tabor
, R.
Murali
, M.
Mahmoud
, and M. A.
El-Sayed
, “On the use of plasmonic nanoparticle pairs as a plasmon ruler: The dependence of the near-field dipole plasmon coupling on nanoparticle size and shape
,” J. Phys. Chem. A
113
, 1946
–1953
(2009
).21.
A.
Dhawan
, S. J.
Norton
, M. D.
Gerhold
, and T.
Vo-Dinh
, “Comparison of FDTD numerical computations and analytical multipole expansion method for plasmonics-active nanosphere dimers
,” Opt. Express
17
, 9688
–9703
(2009
).22.
S. S.
Aćimović
, M. P.
Kreuzer
, M. U.
González
, and R.
Quidant
, “Plasmon near-field coupling in metal dimers as a step toward single-molecule sensing
,” ACS Nano
3
, 1231
–1237
(2009
).23.
D.
Punj
et al, “Self-assembled nanoparticle dimer antennas for plasmonic-enhanced single-molecule fluorescence detection at micromolar concentrations
,” ACS Photonics
2
, 1099
–1107
(2015
).24.
V. V.
Thacker
et al, “DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering
,” Nat. Commun.
5
, 3448
(2014
).25.
H.
Xu
, E. J.
Bjerneld
, M.
Käll
, and L.
Börjesson
, “Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering
,” Phys. Rev. Lett.
83
, 4357
–4360
(1999
).26.
T.
Zhang
, N.
Gao
, S.
Li
, M. J.
Lang
, and Q.-H.
Xu
, “Single-particle spectroscopic study on fluorescence enhancement by plasmon coupled gold nanorod dimers assembled on DNA origami
,” J. Phys. Chem. Lett.
6
, 2043
–2049
(2015
).27.
J.
Wu
et al, “Angle-resolved plasmonic properties of single gold nanorod dimers
,” Nano-Micro Lett.
6
, 372
–380
(2014
).28.
A. M.
Funston
, C.
Novo
, T. J.
Davis
, and P.
Mulvaney
, “Plasmon coupling of gold nanorods at short distances and in different geometries
,” Nano Lett.
9
, 1651
–1658
(2009
).29.
M.
Garai
, N.
Gao
, and Q.-H.
Xu
, “Single-particle spectroscopic studies on two-photon photoluminescence of coupled Au nanorod dimers
,” J. Phys. Chem. C
122
, 23102
–23110
(2018
).30.
L.-Y.
Wang
et al, “Circular differential scattering of single chiral self-assembled gold nanorod dimers
,” ACS Photonics
2
, 1602
–1610
(2015
).31.
W.
Ma
et al, “Chiral plasmonics of self-assembled nanorod dimers
,” Sci. Rep.
3
, 1934
(2013
).32.
Z.
Sun
et al, “pH-controlled reversible assembly and disassembly of gold nanorods
,” Small
4
, 1287
(2008
).33.
P.
Zijlstra
, P. M. R.
Paulo
, K.
Yu
, Q.-H.
Xu
, and M.
Orrit
, “Chemical interface damping in single gold nanorods and its near elimination by tip-specific functionalization
,” Angew. Chem.
51
, 8352
–8355
(2012
).34.
X.
Hu
, W.
Cheng
, T.
Wang
, E.
Wang
, and S.
Dong
, “Well-ordered end-to-end linkage of gold nanorods
,” Nanotechnology
16
, 2164
–2169
(2005
).35.
K. K.
Caswell
, J. N.
Wilson
, U. H. F.
Bunz
, and C. J.
Murphy
, “Preferential end-to-end assembly of gold nanorods by biotin–streptavidin connectors
,” J. Am. Chem. Soc.
125
, 13914
–13915
(2003
).36.
U.
Hohenester
and A.
Trügler
, “MNPBEM—A Matlab toolbox for the simulation of plasmonic nanoparticles
,” Comput. Phys. Commun.
183
, 370
–381
(2012
).37.
W.
Zhu
et al, “Quantum mechanical effects in plasmonic structures with subnanometre gaps
,” Nat. Commun.
7
, 11495
(2016
).38.
L. S.
Slaughter
, Y.
Wu
, B. A.
Willingham
, P.
Nordlander
, and S.
Link
, “Effects of symmetry breaking and conductive contact on the plasmon coupling in gold nanorod dimers
,” ACS Nano
4
, 4657
–4666
(2010
).39.
L.
Shao
et al, “Angle-and energy-resolved plasmon coupling in gold nanorod dimers
,” ACS Nano
4
, 3053
–3062
(2010
).40.
K. C.
Woo
et al, “Universal scaling and Fano resonance in the plasmon coupling between gold nanorods
,” ACS Nano
5
, 5976
–5986
(2011
).41.
F.
Koohyar
, A. A.
Rostami
, M. J.
Chaichi
, and F.
Kiani
, “Study on thermodynamic properties for binary systems of water + L-cysteine hydrochloride monohydrate, glycerol, and D-sorbitol at various temperatures
,” J. Chem.
2013
, 601751
.42.
X.
Wei
et al, “Surface plasmon coupling in end-to-end linked gold nanorod dimers and trimers
,” Phys. Chem. Chem. Phys.
15
, 4258
–4264
(2013
).43.
Y.
Cheng
, M.
Wang
, G.
Borghs
, and H.
Chen
, “Gold nanoparticle dimers for plasmon sensing
,” Langmuir
27
, 7884
–7891
(2011
).44.
T.
Kawawaki
, H.
Zhang
, H.
Nishi
, P.
Mulvaney
, and T.
Tatsuma
, “Potential-scanning localized plasmon sensing with single and coupled gold nanorods
,” J. Phys. Chem. Lett.
8
, 3637
–3641
(2017
).45.
W.
Lee
and D.
Kim
, “Field-matter integral overlap to estimate the sensitivity of surface plasmon resonance biosensors
,” J. Opt. Soc. Am. A
29
, 1367
(2012
).46.
P. M. R.
Paulo
et al, “Tip-specific functionalization of gold nanorods for plasmonic biosensing: Effect of linker chain length
,” Langmuir
33
, 6503
–6510
(2017
).47.
P.
Offermans
et al, “Universal scaling of the figure of merit of plasmonic sensors
,” ACS Nano
5
, 5151
–5157
(2011
).48.
P.
Tuersun
, “Optimizing the figure of merit of gold nanoshell-based refractive index sensing
,” Optik
127
, 250
–253
(2016
).49.
S. M. E.
Peters
, M. A.
Verheijen
, M. W. J.
Prins
, and P.
Zijlstra
, “Strong reduction of spectral heterogeneity of gold bipyramids for single-particle and single-molecule plasmon sensing
,” Nanotechnology
27
, 024001
(2016
).50.
J.-M.
Rye
et al, “Single gold bipyramids on a silanized substrate as robust plasmonic sensors for liquid environments
,” Nanoscale
10
, 16094
–16101
(2018
).51.
P. K.
Jain
and M. A.
El-Sayed
, “Noble metal nanoparticle pairs: Effect of medium for enhanced nanosensing
,” Nano Lett.
8
, 4347
–4352
(2008
).© 2021 Author(s). Published under an exclusive license by AIP Publishing.
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