We apply pulsed-field-gradient NMR (PFG NMR) technique to measure the translational diffusion for both uncharged and charged polysaccharide (Ficoll70) in water. Analysis of the data indicates that the NMR signal attenuation above a certain packing fraction can be adequately fitted with a bi-exponential function. The self-diffusion measurements also show that the Ficoll70, an often-used compact, spherical polysucrose molecule, is itself nonideal, exhibiting signs of both softness and attractive interactions in the form of a stable suspension consisting of monomers and clusters. Further, we can quantify the fraction of monomers and clusters. This work strengthens the picture of the existence of a bound water layer within and around a porous Ficoll70 particle.
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Research Article| August 15 2017
Dynamics and cluster formation in charged and uncharged Ficoll70 solutions
Swomitra Palit ;
Swomitra Palit, Anand Yethiraj; Dynamics and cluster formation in charged and uncharged Ficoll70 solutions. J. Chem. Phys. 21 August 2017; 147 (7): 074901. https://doi.org/10.1063/1.4986366
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