In this work, the chemical changes in calf thymus DNA samples were analyzed by X-ray photoelectron spectroscopy (XPS). The DNA samples were irradiated for over and spectra were taken repeatedly every . In this approach the X-ray beam both damages and probes the samples. In most cases, XPS spectra have complex shapes due to contributions of C, N, and O atoms bonded at several different sites. We show that from a comparative analysis of the modification in XPS line shapes of the C , O , N , and P peaks, one can gain insight into a number of reaction pathways leading to radiation damage to DNA.
X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy
Sylwia Ptasińska, Agnieszka Stypczyńska, Tony Nixon, Nigel J. Mason, Dimitri V. Klyachko, Léon Sanche; X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy. J. Chem. Phys. 14 August 2008; 129 (6): 065102. https://doi.org/10.1063/1.2961027
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