Channel-facilitated membrane transport: Average lifetimes in the channel Available to Purchase

The transport of many solutes across biological membranes happens with the help of specialized proteins that form water-filled channels traversing the membranes. Recent experimental and theoretical work demonstrates that solute translocation can be facilitated by attractive interactions between the channel and penetrating particle. Here we consider an important aspect of channel-facilitated passive transport, the average lifetimes in the channel for those particles that traverse the channel and those that return, as well as the total average lifetime of the particle in the channel. Exact expressions for the average lifetimes are derived in the framework of a one-dimensional diffusion model. The validity of our one-dimensional analysis is verified by good agreement of the theoretical predictions with the average lifetimes found in three-dimensional Brownian dynamics simulations.