Sensors based on nanogap capacitance changes are being developed for genomic and proteomic applications because they offer label-free detection on platforms amenable to high throughput configurations. We compare impedance spectroscopy measurements with a rigorously characterized model that predicts the impedance spectrum of these devices based on geometry. Sensitivity to permittivity changes is also predicted by the model and compared to the measured values in the frequency range from to . The lowest detection limit for the magnitude of the impedance is in the region of , and was measured to be a 1.7% change in permittivity across different devices.
REFERENCES
1.
C.
Berggren
, B.
Bjarnason
, and G.
Johansson
, Electroanalysis
13
, 173
(2001
).2.
E.
Katz
and I.
Willner
, Electroanalysis
15
, 913
(2003
).3.
Y.
Feldman
, I.
Ermolina
, and Y.
Hayashi
, IEEE Trans. Dielectr. Electr. Insul.
10
, 728
(2003
).4.
A.
Oleinikova
, P.
Sasisanker
, and H.
Weingartner
, J. Phys. Chem. B
108
, 8467
(2004
).5.
G.
Smith
, A. P.
Duffy
, J.
Shen
, and C. J.
Olliff
, J. Pharm. Sci.
84
, 1029
(1995
).6.
A.
Bonincontro
and G.
Risuleo
, Spectrochim. Acta, Part A
59
, 2677
(2003
).7.
O. A.
Sadik
, H.
Xu
, E.
Gheorghiu
, D.
Andreescu
, C.
Balut
, M.
Gheorghiu
, and D.
Bratu
, Anal. Chem.
74
, 3142
(2002
).8.
F.
Patolsky
, B.
Filanovsky
, E.
Katz
, and I.
Willner
, J. Phys. Chem. B
102
, 10359
(1998
).9.
Y.
Otsuka
, Y.
Naitoh
, T.
Matsumoto
, W.
Mizutani
, H.
Tabata
, and T.
Kawai
, Nanotechnology
15
, 1639
(2004
).10.
S. M.
Iqbal
, G.
Balasundaram
, S.
Ghosh
, D. E.
Bergstrom
, and R.
Bashir
, Appl. Phys. Lett.
86
, 153901
(2005
).11.
A.
Malave
, M.
Tewes
, T.
Gronewold
, and M.
Lohndorf
, Microelectron. Eng.
78,79
, 587
(2005
).12.
J. T.
Nevill
, D. Di
Carlo
, P.
Liu
, K. H.
Jeong
, and L. P.
Lee
, IEEE Transducers 2
, 1668
(2005
).13.
M. Q.
Yi
, K. H.
Jeong
, and L. P.
Lee
, Biosens. Bioelectron.
20
, 1320
(2005
).14.
S. E.
Babayan
, J. Y.
Jeong
, V. J.
Tu
, J.
Park
, G. S.
Selwyn
, and R. F.
Hicks
, Plasma Sources Sci. Technol.
7
, 286
(1998
).15.
K. R.
Williams
, K.
Gupta
, and M.
Wasilik
, J. Microelectromech. Syst.
12
, 761
(2003
).16.
S.
Bone
, J.
Eden
, and R.
Pethig
, Int. J. Quantum Chem. 307
(1981
).17.
D.
Rosen
, Trans. Faraday Soc.
59
, 2178
(1963
).18.
S.
Takashima
and H. P.
Schwan
, J. Phys. Chem.
69
, 4176
(1965
).© 2006 American Institute of Physics.
2006
American Institute of Physics
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