We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500 m. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.
Ultrasound-based surface sampling in immersion for mass spectrometry
Tom Sillanpää, Jere Hyvönen, Joni Mäkinen, Axi Holmström, Topi Pudas, Petri Lassila, Riikka Lepistö, Antti Kuronen, Tapio Kotiaho, Edward Hæggström, Ari Salmi; Ultrasound-based surface sampling in immersion for mass spectrometry. J. Appl. Phys. 14 September 2023; 134 (10): 104901. https://doi.org/10.1063/5.0157705
Download citation file: