Monte Carlo track structure simulation is a powerful method for estimating damage induced by water radiolysis products for cell killing. To investigate the influence of multiple ionization for the formation of water radiolysis products under 1H+, 4He2+, and 12C6+ ion beams, a Monte Carlo simulation based on Geant4-DNA was carried out. The G-value of H2O2 increased monotonically with increasing linear energy transfer up to 200 eV/nm. Above 200 eV/nm, the G-value of H2O2 began dropping, but only when the influence of multiple ionization was considered. This trend is in good agreement with the experimental results. Furthermore, we successfully reproduce the experimental results of G-values of HO2• + O2•−. The role of the multiple ionization in the production of H2O2, HO2•, O2•−, and O2 is also discussed.
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28 June 2021
Research Article|
June 30 2021
A simulation-based study on water radiolysis species for 1H+, 4He2+, and 12C6+ ion beams with multiple ionization using Geant4-DNA
Kentaro Baba
;
Kentaro Baba
1
Graduate School of Biomedical Science and Engineering, Hokkaido University
, Kita-15 Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan
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Tamon Kusumoto
;
Tamon Kusumoto
2
National Institutes for Quantum and Radiological Science and Technology
, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan
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Shogo Okada
;
Shogo Okada
3
High Energy Accelerator Research Organization (KEK)
, 1-1, Oho, Tsukuba, Ibaraki 305-0801, Japan
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Masayori Ishikawa
Masayori Ishikawa
a)
1
Graduate School of Biomedical Science and Engineering, Hokkaido University
, Kita-15 Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan
4
Faculty of Health Sciences, Hokkaido University
, Kita-12 Nishi-5, Kita-ku, Sapporo, Hokkaido 060-0812, Japan
a)Author to whom correspondence should be addressed: [email protected]
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a)Author to whom correspondence should be addressed: [email protected]
J. Appl. Phys. 129, 244702 (2021)
Article history
Received:
April 20 2021
Accepted:
June 10 2021
Citation
Kentaro Baba, Tamon Kusumoto, Shogo Okada, Masayori Ishikawa; A simulation-based study on water radiolysis species for 1H+, 4He2+, and 12C6+ ion beams with multiple ionization using Geant4-DNA. J. Appl. Phys. 28 June 2021; 129 (24): 244702. https://doi.org/10.1063/5.0054665
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