Plasmonic materials and phenomena have been widely studied and applied in multiple fields for a long time. One of the most promising applications is in the engineering of biosensor devices, offering label-free and real-time analysis of biomolecular interactions with excellent performances. In this tutorial, we provide a pedagogical review of the working principles of plasmonic biosensors, main fabrication methods, instrumentation, and general guidelines for their development. Special focus is placed on the biosensor performance characterization and assessment, as well as on the sensor surface biofunctionalization. In the end, we discuss the common procedure to develop and validate biosensors for relevant biomedical and environmental purposes and future perspectives in terms of boosting capabilities and sensor integration in point-of-care platforms.
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21 March 2021
Tutorial|
March 17 2021
Principles, technologies, and applications of plasmonic biosensors
Special Collection:
Plasmonics: Enabling Functionalities with Novel Materials
Maria Soler
;
Maria Soler
a)
Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2)
, CSIC, BIST and CIBER-BBN, Bellaterra, Barcelona 08193, Spain
a)Author to whom correspondence should be addressed: maria.soler@icn2.cat
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Laura M. Lechuga
Laura M. Lechuga
Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2)
, CSIC, BIST and CIBER-BBN, Bellaterra, Barcelona 08193, Spain
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a)Author to whom correspondence should be addressed: maria.soler@icn2.cat
J. Appl. Phys. 129, 111102 (2021)
Article history
Received:
January 04 2021
Accepted:
March 03 2021
Citation
Maria Soler, Laura M. Lechuga; Principles, technologies, and applications of plasmonic biosensors. J. Appl. Phys. 21 March 2021; 129 (11): 111102. https://doi.org/10.1063/5.0042811
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