Whispering gallery mode microresonators coupled to plasmonic nanoparticles have shown great promise for ultra-sensitive and label-free biological sensing. We analyze a whispering gallery mode microtoroid biosensor with a triangular gold nanoprism bound to its surface. We choose triangular nanoprism because of its capability of considerable enhancement of electromagnetic field at the tips and because its localized surface plasmon resonance band position is readily tunable. The local electric field enhancement at different points of plasmonic triangular gold nanoprism is calculated and the effect of rounded tip is investigated. This field enhancement permits the detection and characterization of some large protein molecules. We have studied the detection of single bovine serum albumin protein using our hybrid microcavity.

Topics
Plasmonics, Whispering gallery wave, Superconducting microresonators, Electromagnetism, Nanoparticle, Microoptics, Transition metals, Experimental serum, Proteins, Biosensors
1.
B. M.
 
Willardson
,
J. F.
 
Wilkins
,
T. A.
 
Rand
,
J. M.
 
Schupp
,
K. K.
 
Hill
,
P.
 
Keim
, and
P. J.
 
Jackson
,
Appl. Environ. Microbiol.
 
64
(
3
),
1006
(
1998
).
Google Scholar
Crossref
Search ADS
PubMed
 
2.
J.
 
Tschmelak
,
G.
 
Proll
, and
G.
 
Gauglitz
,
Anal. Chim. Acta
 
519
(
2
),
143
(
2004
).
https://doi.org/10.1016/j.aca.2004.06.031
Google Scholar
Crossref
Search ADS
 
3.
A. J.
 
Baeumner
,
R. N.
 
Cohen
,
V.
 
Miksic
, and
J.
 
Min
,
Biosens. Bioelectron.
 
18
,
405
(
2003
).
https://doi.org/10.1016/S0956-5663(02)00162-8
Google Scholar
Crossref
Search ADS
PubMed
 
4.
Y. M.
 
Bae
,
B. K.
 
Oh
,
W.
 
Lee
,
W. H.
 
Lee
, and
J. W.
 
Choi
,
Biosens. Bioelectron.
 
20
(
4
),
895
(
2004
).
https://doi.org/10.1016/j.bios.2004.03.032
Google Scholar
Crossref
Search ADS
PubMed
 
5.
M.
 
Baaske
 and
F.
 
Vollmer
,
ChemPhysChem
 
13
,
427
(
2012
).
https://doi.org/10.1002/cphc.201100757
Google Scholar
Crossref
Search ADS
PubMed
 
6.
T.
 
Yoshie
,
L. L.
 
Tang
, and
S. Y.
 
Su
,
Sensors
 
11
,
1972
(
2011
).
https://doi.org/10.3390/s110201972
Google Scholar
Crossref
Search ADS
PubMed
 
7.
A.
 
Chiasera
,
Y.
 
Dumeige
,
P.
 
Feron
,
M.
 
Ferrari
,
Y.
 
Jestin
,
G. N.
 
Conti
,
S.
 
Pelli
,
S.
 
Soria
, and
G. C.
 
Righini
,
Laser Photonics Rev.
 
4
,
457
(
2010
).
https://doi.org/10.1002/lpor.200910016
Google Scholar
Crossref
Search ADS
 
8.
F.
 
Vollmer
 and
S.
 
Arnold
,
Nat. Methods
 
5
,
591
(
2008
).
https://doi.org/10.1038/nmeth.1221
Google Scholar
Crossref
Search ADS
PubMed
 
9.
F.
 
Vollmer
,
S.
 
Arnold
, and
D.
 
Keng
,
Proc. Natl. Acad. Sci. U.S.A.
 
105
(
52
),
20701
(
2008
).
https://doi.org/10.1073/pnas.0808988106
Google Scholar
Crossref
Search ADS
PubMed
 
10.
S.
 
Arnold
,
M.
 
Khoshsima
,
I.
 
Teraoka
,
S.
 
Holler
, and
F.
 
Vollmer
,
Opt. Lett.
 
28
(
4
),
272
(
2003
).
https://doi.org/10.1364/OL.28.000272
Google Scholar
Crossref
Search ADS
PubMed
 
11.
Y.
 
Hu
,
L.
 
Shao
,
S.
 
Arnold
,
Y.-C.
 
Liu
,
C.-Y.
 
Ma
, and
Y.-F.
 
Xiao
,
Phys. Rev. A
 
90
,
043847
(
2014
).
https://doi.org/10.1103/PhysRevA.90.043847
Google Scholar
Crossref
Search ADS
 
12.
I.
 
Teraoka
 and
S.
 
Arnold
,
J. Opt. Soc. Am. B
 
23
,
1381
(
2006
).
https://doi.org/10.1364/JOSAB.23.001381
Google Scholar
Crossref
Search ADS
 
13.
J. T.
 
Rubin
 and
L.
 
Deych
,
Phys. Rev. A
 
81
,
053827
(
2010
).
https://doi.org/10.1103/PhysRevA.81.053827
Google Scholar
Crossref
Search ADS
 
14.
Y.-F.
 
Xiao
,
Y.-C.
 
Liu
,
B.-B.
 
Li
,
Y.-L.
 
Chen
,
Y.
 
Li
, and
Q.
 
Gong
,
Phys. Rev. A
 
85
,
031805
(
2012
).
https://doi.org/10.1103/PhysRevA.85.031805
Google Scholar
Crossref
Search ADS
 
15.
M. R.
 
Foreman
 and
F.
 
Vollmer
,
New J. Phys
 
15
,
083006
(
2013
).
https://doi.org/10.1088/1367-2630/15/8/083006
Google Scholar
Crossref
Search ADS
 
16.
S. I.
 
Shopova
,
R.
 
Rajmangal
,
S.
 
Holler
, and
S.
 
Arnold
,
Appl. Phys. Lett.
 
98
,
243104
(
2011
).
https://doi.org/10.1063/1.3599584
Google Scholar
Crossref
Search ADS
 
17.
V. R.
 
Dantham
,
S.
 
Holler
,
V.
 
Kolchenko
,
Z.
 
Wan
, and
S.
 
Arnold
,
Appl. Phys. Lett.
 
101
(
4
),
043704
(
2012
).
https://doi.org/10.1063/1.4739473
Google Scholar
Crossref
Search ADS
 
18.
V. R.
 
Dantham
,
S.
 
Holler
,
C.
 
Barbre
,
D.
 
Keng
,
V.
 
Kolchenko
, and
S.
 
Arnold
,
Nano Lett.
 
13
(
7
),
3347
(
2013
).
https://doi.org/10.1021/nl401633y
Google Scholar
Crossref
Search ADS
PubMed
 
19.
J. D.
 
Swaim
,
J.
 
Knittel
, and
W. P.
 
Bowen
,
Appl. Phys. Lett.
 
99
,
243109
(
2011
).
https://doi.org/10.1063/1.3669398
Google Scholar
Crossref
Search ADS
 
20.
P.
 
Zijlstra
,
P. M. R.
 
Paulo
, and
M.
 
Orrit
,
Nat. Nanotechnol.
 
7
,
379
(
2012
).
https://doi.org/10.1038/nnano.2012.51
Google Scholar
Crossref
Search ADS
PubMed
 
21.
S.
 
Arnold
,
V. R.
 
Dantham
,
C.
 
Barbre
,
B. A.
 
Garetz
, and
X. D.
 
Fan
,
Opt. Express
 
20
(
24
),
26147
(
2012
).
https://doi.org/10.1364/OE.20.026147
Google Scholar
Crossref
Search ADS
PubMed
 
22.
M. D.
 
Baaske
,
M. R.
 
Foreman
, and
F.
 
Vollmer
,
Nat. Nanotechnol.
 
9
,
933
–
939
(
2014
).
https://doi.org/10.1038/nnano.2014.180
Google Scholar
Crossref
Search ADS
PubMed
 
23.
A.
 
Singh
,
M.
 
Chaudhari
, and
M.
 
Sastry
,
Nanotechnology
 
17
,
2399
(
2006
).
https://doi.org/10.1088/0957-4484/17/9/055
Google Scholar
Crossref
Search ADS
 
24.
H.
 
Jing
,
L.
 
Zhang
, and
H.
 
Wang
,
Geometrically Tunable Optical Properties of Metal Nanoparticles
(
Springer-Verlag
,
Berlin, Heidelberg
,
2013
).
Google Scholar
Crossref
Search ADS
 
25.
E. C.
 
Le Ru
 and
P. G.
 
Etchegoin
,
Principles of Surface-Enhanced Raman Spectroscopy and Related Plasmonic Effects
(
Elsevier
,
Amsterdam
,
2009
).
Google Scholar
 
26.
D. K.
 
Armani
,
T. J.
 
Kippenberg
,
S. M.
 
Spillane
, and
K. J.
 
Vahala
,
Nature
 
421
,
925
(
2003
).
https://doi.org/10.1038/nature01371
Google Scholar
Crossref
Search ADS
PubMed
 
27.
A. B.
 
Matsko
 and
V. S.
 
Ilchenko
,
IEEE J. Sel. Top. Quantum Electron.
 
12
,
3
–
14
(
2006
).
https://doi.org/10.1109/JSTQE.2005.862952
Google Scholar
Crossref
Search ADS
 
28.
M.
 
Oxborrow
,
IEEE Trans. Microwave Theory Tech.
 
55
,
1209
(
2007
).
https://doi.org/10.1109/TMTT.2007.897850
Google Scholar
Crossref
Search ADS
 
29.
A.
 
Kaplan
,
M.
 
Tomes
,
T.
 
Carmon
,
M.
 
Kozlov
,
O.
 
Cohen
,
G.
 
Bartal
, and
H. G. L.
 
Schwefel
,
Opt. Express
 
21
,
14169
(
2013
).
https://doi.org/10.1364/OE.21.014169
Google Scholar
Crossref
Search ADS
PubMed
 
30.
X.
 
Du
,
S.
 
Vincent
, and
T.
 
Lu
,
Opt. Express
 
21
(
19
),
22012
(
2013
)
https://doi.org/10.1364/OE.21.022012
.
Google Scholar
Crossref
Search ADS
PubMed
 
31.
E. D.
 
Palik
,
Handbook of Optical Constants of Solids
(
Academic Press
,
Boston
,
1985
).
Google Scholar
 
32.
U.
 
Hohenester
 and
A.
 
Trügler
,
Comput. Phys. Commun.
 
183
,
370
(
2012
).
https://doi.org/10.1016/j.cpc.2011.09.009
Google Scholar
Crossref
Search ADS
 
33.
F. J.
 
Garcia de Abajo
 and
A.
 
Howie
,
Phys. Rev. B
 
65
,
115418
(
2002
).
https://doi.org/10.1103/PhysRevB.65.115418
Google Scholar
Crossref
Search ADS
 
34.
F. J. G.
 
de Abajo
,
Rev. Mod. Phys.
 
82
,
209
(
2010
).
https://doi.org/10.1103/RevModPhys.82.209
Google Scholar
Crossref
Search ADS
 
35.
D. M.
 
Pozar
,
Microwave Engineering
(
Wiley
,
1998
).
Google Scholar
 
36.
F.
 
Vollmer
,
B. I. F. Futura
 
20
,
239
(
2005
).
Google Scholar
 
37.
J.
 
Jackson
,
Classical Electrodynamics
(
Wiley
,
New York
,
1999
).
Google Scholar
 
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