When imaging soft tissues with hard X-rays, phase contrast is often preferred over conventional attenuation contrast due its superior sensitivity. However, it is unclear which of the numerous phase tomography methods yields the optimized results at given experimental conditions. Therefore, we quantitatively compared the three phase tomography methods implemented at the beamline ID19 of the European Synchrotron Radiation Facility: X-ray grating interferometry (XGI), and propagation-based phase tomography, i.e., single-distance phase retrieval (SDPR) and holotomography (HT), using cancerous tissue from a mouse model and an entire heart of a rat. We show that for both specimens, the spatial resolution derived from the characteristic morphological features is about a factor of two better for HT and SDPR compared to XGI, whereas the XGI data generally exhibit much better contrast-to-noise ratios for the anatomical features. Moreover, XGI excels in fidelity of the density measurements, and is also more robust against low-frequency artifacts than HT, but it might suffer from phase-wrapping artifacts. Thus, we can regard the three phase tomography methods discussed as complementary. The application will decide which spatial and density resolutions are desired, for the imaging task and dose requirements, and, in addition, the applicant must choose between the complexity of the experimental setup and the one of data processing.
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Experimental comparison of grating- and propagation-based hard X-ray phase tomography of soft tissue
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21 October 2014
Research Article|
October 21 2014
Experimental comparison of grating- and propagation-based hard X-ray phase tomography of soft tissue
S. Lang;
S. Lang
1Biomaterials Science Center,
University of Basel
, Basel, Switzerland
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I. Zanette;
I. Zanette
a)
2Physik-Department und Institut für Medizintechnik,
Technische Universität München
, Garching, Germany
3
European Synchrotron Radiation Facility
, Grenoble, France
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M. Dominietto;
M. Dominietto
1Biomaterials Science Center,
University of Basel
, Basel, Switzerland
4
Institute for Biomedical Engineering
, ETH Zürich, Zürich, Switzerland
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M. Langer;
M. Langer
3
European Synchrotron Radiation Facility
, Grenoble, France
5
Université de Lyon
, CREATIS; CNRS UMR5220; Inserm U1044; INSA-LYON; Université de Lyon 1, Villeurbane, France
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A. Rack;
A. Rack
3
European Synchrotron Radiation Facility
, Grenoble, France
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G. Schulz;
G. Schulz
1Biomaterials Science Center,
University of Basel
, Basel, Switzerland
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G. Le Duc;
G. Le Duc
3
European Synchrotron Radiation Facility
, Grenoble, France
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C. David;
C. David
6Laboratory for Micro- and Nanotechnology,
Paul Scherrer Institut
, Villigen, Switzerland
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J. Mohr;
J. Mohr
7
Institute of Microstructure Technology, Karlsruhe Institute of Technology
, Eggenstein-Leopoldshafen, Germany
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F. Pfeiffer;
F. Pfeiffer
2Physik-Department und Institut für Medizintechnik,
Technische Universität München
, Garching, Germany
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B. Müller;
B. Müller
1Biomaterials Science Center,
University of Basel
, Basel, Switzerland
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T. Weitkamp
T. Weitkamp
3
European Synchrotron Radiation Facility
, Grenoble, France
8
Synchrotron Soleil
, Gif-sur-Yvette, France
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a)
Electronic mail: [email protected]
J. Appl. Phys. 116, 154903 (2014)
Article history
Received:
April 27 2014
Accepted:
September 24 2014
Citation
S. Lang, I. Zanette, M. Dominietto, M. Langer, A. Rack, G. Schulz, G. Le Duc, C. David, J. Mohr, F. Pfeiffer, B. Müller, T. Weitkamp; Experimental comparison of grating- and propagation-based hard X-ray phase tomography of soft tissue. J. Appl. Phys. 21 October 2014; 116 (15): 154903. https://doi.org/10.1063/1.4897225
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