The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, and thermo gravimetric analysis (TGA). FT-IR and TGA measurements show good adsorption of drugs on oleic acid coated nanoparticles. Magnetic measurements indicate that saturation magnetization is larger for amoxicillin coated particles compared to folic acid coated particles. The biocompatibility of the magnetic nanoparticles prepared was evaluated by in vitro cytotoxicity assay using L929 cells as model cells.

1.
A. K.
Gupta
and
M.
Gupta
,
Biomaterials
26
,
3995
(
2005
).
2.
Q. A.
Pankhurst
 et al.,
J. Phys. D: Appl. Phys.
36
,
R167
(
2003
).
3.
B.
Ankamwar
 et al.,
Nanotechnology
21
,
075102
(
2010
).
5.
W.
Zhang
,
J. Nanopart. Res.
5
,
323
(
2003
).
6.
M.
Dickinson
and
T. B.
Scott
,
J. Hazard. Mater.
178
,
171
(
2010
).
7.
M.
Chen
 et al.,
J. Appl. Phys.
93
,
7551
(
2003
).
8.
M.
Maeda
 et al.,
J. Appl. Phys.
99
,
08H103
(
2006
).
9.
S. D.
Weitman
 et al.,
Cancer Res.
52
,
3396
(
1992
).
10.
P. R.
Twentyman
and
M.
Luscombe
,
Br. J. Cancer
56
(
3
),
279
(
1987
).
11.
T. L.
Riss
 et al., “
Cell viability assays
” in
Assay Guidance Manual [Internet]
, edited by
G. S.
Sittampalam
,
N.
Gal-Edd
,
M.
Arkin
 et al. (
Eli Lilly & Company and the National Center for Advancing Translational Sciences
,
Bethesda, MD
,
2004
).
12.
13.
M.
Bloemen
 et al.,
J. Nanopart. Res.
14
(
9
),
1100
(
2012
).
14.
L.
Zhang
 et al.,
Appl. Surf. Sci.
253
,
2611
(
2006
).
15.
16.
S. Z.
Qureshi
 et al.,
J. Pharm. Biomed. Anal.
21
,
473
(
1999
).
17.
Q.
Lan
 et al.,
J. Colloid Interface Sci.
310
,
260
(
2007
).
18.
S. M.
de Lacerda Gontijo
 et al.,
Electron. J. Biotechnol.
16
,
2
(
2013
).
19.
A. G.
Kolhatkar
 et al.,
Int. J. Mol. Sci.
14
,
15977
(
2013
).
You do not currently have access to this content.