A multi-layered metal-insulator-metal plasmonic Mach-Zehnder interferometer (MZI) is proposed to work as an array for multiplexed sensing. The interference patterns based on wavelength modulation and intensity modulation are modeled analytically and numerically, showing a high figure of merit over 170 for intensity-interrogated sensing. The proposed structure can overcome the one-slit illumination limitation of previously reported single-layered double-slit plasmonic MZI and will enable portable, high-throughput and sensitive biosensing applications.
REFERENCES
1.
H.
Raether
, Surface Plasmons on Smooth and Rough Surfaces and on Gratings
(Springer-Verlag
, Berlin
, 1988
).2.
J.
Homola
, “Surface plasmon resonance sensors for detection of chemical and biological species
,” Chem. Rev.
108
(2
), 462
–493
(2008
).3.
See http://www.biacore.com for the detection limit of commercial facilities.
4.
J.
Ji
, J. G.
O'Connell
, D. J.
Carter
, and D. N.
Larson
, “High-throughput nanohole array based system to monitor multiple binding events in real time
,” Anal. Chem.
80
(7
), 2491
–2498
(2008
).5.
H.
Im
, A.
Lesuffleur
, N. C.
Lindquist
, and S. H.
Oh
, “Plasmonic nanoholes in a multichannel microarray format for parallel kinetic assays and differential sensing
,” Anal. Chem.
81
(8
), 2854
–2859
(2009
).6.
E. M.
Larsson
, C.
Langhammer
, I.
Zorić
, and B.
Kasemo
, “Nanoplasmonic probes of catalytic reactions
,” Science
326
, 1091
(2009
).7.
R.
Adato
, A. A.
Yanik
, J. J.
Amsden
, D. L.
Kaplan
, F. G.
Omenetto
, M. K.
Hong
, S.
Erramilli
, and H.
Altug
, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays
,” Proc. Natl. Acad. Sci. U.S.A.
106
, 19227
(2009
).8.
E.
Hendry
, T.
Carpy
, J.
Johnston
, M.
Popland
, R. V.
Mikhaylovskiy
, A. J.
Lapthorn
, S. M.
Kelly
, L. D.
Barron
, N.
Gadegaard
, and M.
Kadodwala
, “Ultrasensitive detection and characterization of biomolecules using superchiral fields
,” Nat. Nanotechnol.
5
(11
), 783
–787
(2010
).9.
A. A.
Yanik
, M.
Huang
, O.
Kamohara
, A.
Artar
, T. W.
Geisbert
, J. H.
Connor
, and H.
Altug
, “An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media
,” Nano Lett.
10
(12
), 4962
–4969
(2010
).10.
J.
Homola
, Surface Plasmon Resonance Based Sensors
(Springer
, Berlin
, 2006
).11.
M. E.
Stewart
, C. R.
Anderton
, L. B.
Thompson
, J.
Maria
, S. K.
Gray
, J. A.
Rogers
, and R. G.
Nuzzo
, “Nanostructured plasmonic sensors
,” Chem. Rev.
108
, 494
(2008
).12.
J. N.
Anker
, W. P.
Hall
, O.
Lyandres
, N. C.
Shah
, J.
Zhao
, and R. P.
Van Duyne
, “Biosensing with plasmonic nanosensors
,” Nature Mater.
7
, 442
(2008
).13.
M. E.
Stewart
, N. H.
Mack
, V.
Malyarchuk
, J. A. N.
Soares
, T. W.
Lee
, S. K.
Gray
, R. G.
Nuzzo
, and J. A.
Rogers
, “Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals
,” Proc. Natl. Acad. Sci. U.S.A.
103
(46
), 17143
–17148
(2006
).14.
J. C.
Yang
, J.
Ji
, J. M.
Hogel
, and D. N.
Larson
, “Metallic nanohole arrays on fluoropolymer substrates as small label-free real time bioprobes
,” Nano Lett.
8
(9
), 2718
–2724
(2008
).15.
A.
Lesuffleur
, H.
Im
, N. C.
Lindquist
, and S. H.
Oh
, “Periodic nanohole arrays with shape-enhanced plasmon resonance as real-time biosensors
,” Appl. Phys. Lett.
90
(24
), 243110
–243113
(2007
).16.
A. G.
Brolo
, R.
Gordon
, B.
Leathem
, and K. L.
Kavanagh
, “Surface plasmon sensor based on the enhanced light transmission through arrays of nanoholes in gold films
,” Langmuir
20
(12
), 4813
–4815
(2004
).17.
A. D.
Leebeek
, L. K.
Swaroop Kumar
, V.
Lange
, D.
Sinton
, R.
Gordon
, and A. G.
Brolo
, “On-chip surface-based detection with nanohole array
,” Anal. Chem.
79
(11
), 4094
–4100
(2007
).18.
J. C.
Sharpe
, J. S.
Mitchell
, L.
Lin
, N.
Sedoglavich
, and R. J.
Blaikie
, “Gold nanohole array substrates as immunobiosensors
,” Anal. Chem.
80
(6
), 2244
–2249
(2008
).19.
G. M.
Hwang
, L.
Pang
, E. H.
Mullen
, and Y.
Fainman
, “Plasmonic sensing of biological analytes through nanoholes
,” IEEE Sens. J.
8
(12
), 2074
–2079
(2008
).20.
J.
Henzie
, M. H.
Lee
, and T. W.
Odom
, “Multiscale patterning of plasmonic metamaterials
,” Nat. Nanotechol.
2
(9
), 549
–554
(2007
).21.
K. A.
Tetz
, L.
Pang
, and Y.
Fainman
, “High-resolution surface plasmon resonance sensor based on linewidth optimized nanohole array transmittance
,” Opt. Lett.
31
(10
), 1528
–1530
(2006
).22.
N.
Liu
, M.
Mesch
, T.
Weiss
, M.
Hentschel
, and H.
Giessen
, “Infrared perfect absorber and its application as plasmonic sensor
,” Nano Lett.
10
(7
), 2342
–2348
(2010
).23.
M. H.
Lee
, H.
Gao
, and T. W.
Odom
, “Refractive index sensing using quasi one-dimensional nanoslit arrays
,” Nano Lett.
9
, 2584
(2009
).24.
J.
Homola
, S. S.
Yee
, and G.
Gauglitz
, “Surface plasmon resonance sensors: Review
,” Sens. Actuators B
54
(1–2
), 3
–15
(1999
).25.
H. F.
Schouten
, N.
Kuzmin
, G.
Dubois
, T. D.
Visser
, G.
Gbur
, P. F. A.
Alkemade
, H.
Blok
, G. W.
t. Hooft
, D.
Lenstra
, and E. R.
Eliel
, “Plasmon-assisted two-slit transmission: Young's experiment revisited
,” Phys. Rev. Lett.
94
(5
), 053901
(2005
).26.
X.
Wu
, J.
Zhang
, J.
Chen
, C.
Zhao
, and Q.
Gong
, “Refractive index sensor based on surface-plasmon interference
,” Opt. Lett.
34
(3
), 392
–394
(2009
).27.
Q.
Gan
, Y.
Gao
, and F. J.
Bartoli
, “Vertical plasmonic Mach-Zehnder interferometer for ultra-sensitive optical sensing
,” Opt. Express
17
(23
), 20747
–20755
(2009
).28.
Y.
Gao
, Q.
Gan
, Z.
Xin
, X.
Cheng
, and F. J.
Bartoli
, “Plasmonic Mach-Zehnder interferometer for sensitive on-chip biosensing
,” ACS Nano
5
(12
), 9836
–9844
(2011
).29.
B.
Prade
, J. Y.
Vinet
, and A.
Mysyrowicz
, “Guided optical waves in planar heterostructures with negative dielectric constant
,” Phys. Rev. B
44
, 13556
(1991
).30.
P.
Ginzburg
, D.
Arbel
, and M.
Orenstein
, “Gap plasmon polariton structure for very efficient microscale-to-nanoscale interfacing
,” Opt. Lett.
31
, 3288
(2006
).31.
S. A.
Maier
, Plasmonics: Fundamentals and Applications
(Springer
, New York
, 2007
).32.
A. W.
Snyder
and J. D.
Love
, Optical Waveguide Theory
(Chapman and Hall
, New York
, 1983
).33.
P.
Lalanne
, J. P.
Hugonin
, and J. C.
Rodier
, “Theory of surface plasmon generation at nanoslit apertures
,” Phys. Rev. Lett.
95
(26
), 263902
(2005
).34.
H.
Hu
, X.
Zeng
, L.
Wang
, Y.
Xu
, G.
Song
, and Q.
Gan
, “Surface plasmon coupling efficiency from nanoslit apertures to metal-insulator-metal waveguides
,” Appl. Phys. Lett.
101
(12
), 121112
–121115
(2012
).35.
N. C.
Lindquist
, A.
Lesuffleur
, H.
Im
, and S. H.
Oh
, “Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation
,” Lab Chip
9
, 382
(2009
).36.
A. G.
Brolo
, “Plasmonics for future biosensors
,” Nat. Photonics
6
(11
), 709
–713
(2012
).37.
Q.
Gan
and F.
Bartoli
, “Bidirectional surface wave splitter at visible frequencies
,” Opt. Lett.
35
, 4181
(2010
).38.
Q.
Gan
, B.
Guo
, G.
Song
, L.
Chen
, Z.
Fu
, Y. J.
Ding
, and F. J.
Bartoli
, “Plasmonic surface-wave splitter
,” Appl. Phys. Lett.
90
, 161130
(2007
).39.
Q.
Gan
, Y.
Gao
, K.
Wagner
, D.
Vezenov
, Y. J.
Ding
, and F. J.
Bartoli
, “Experimental verification of the rainbow trapping effect in adiabatic plasmonic gratings
,” Proc. Natl. Acad. Sci. U.S.A.
108
(13
), 5169
–5173
(2011
).40.
F.
López-Tejeira
, F. J.
García-Vidal
, and L.
Martín-Moreno
, “Scattering of surface plasmons by one-dimensional periodic nanoindented surfaces
,” Phys. Rev. B
72
(16
), 161405
(2005
).41.
G.
Li
, L.
Cai
, F.
Xiao
, Y.
Pei
, and A.
Xu
, “A quantitative theory and the generalized Bragg condition for surface plasmon Bragg reflectors
,” Opt. Express
18
(10
), 10487
–10499
(2010
).42.
J.
Becker
, A.
Trügler
, A.
Jakab
, U.
Hohenester
, and C.
Sönnichsen
, “The optimal aspect ratio of gold nanorods for plasmonic bio-sensing
,” Plasmonics
5
(2
), 161
–167
(2010
).43.
H.
Zhu
, S. O.
Isikman
, O.
Mudanyali
, A.
Greenbaum
, and A.
Ozcan
, “Optical imaging techniques for point-of-care diagnostics
,” Lab Chip
13
(1
), 51
–67
(2013
).© 2013 American Institute of Physics.
2013
American Institute of Physics
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