Magnetic nanoparticles can create heat that can be exploited to treat cancer when they are exposed to alternating magnetic fields (AMF). At a fixed frequency, the particle heating efficiency or specific power loss (SPL) depends upon the magnitude of the AMF. We characterized the amplitude-dependent SPL of three commercial dextran-iron oxide nanoparticle suspensions through saturation to 94 kA/m with a calorimeter comprising a solenoid coil that generates a uniform field to 100 kA/m at ∼150 kHz. We also describe a novel method to empirically determine the appropriate range of the heating curve from which the SPL is then calculated. These results agree with SPL values calculated from the phenomenological Box-Lucas equation. We note that the amplitude-dependent SPL among the samples was markedly different, indicating significant magneto-structural variation not anticipated by current models.
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15 June 2011
Research Article|
June 21 2011
Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields
David E. Bordelon;
David E. Bordelon
1
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
, Baltimore, Maryland, USA
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Christine Cornejo;
Christine Cornejo
1
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
, Baltimore, Maryland, USA
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Cordula Grüttner;
Cordula Grüttner
2
Micromod Partikeltechnologie, GmbH
, Rostock, Germany
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Fritz Westphal;
Fritz Westphal
2
Micromod Partikeltechnologie, GmbH
, Rostock, Germany
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Theodore L. DeWeese;
Theodore L. DeWeese
1
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
, Baltimore, Maryland, USA
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Robert Ivkov
Robert Ivkov
a)
1
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
, Baltimore, Maryland, USA
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a)
Author to whom correspondence should be addressed. Electronic mail: [email protected].
J. Appl. Phys. 109, 124904 (2011)
Article history
Received:
February 18 2011
Accepted:
May 05 2011
Citation
David E. Bordelon, Christine Cornejo, Cordula Grüttner, Fritz Westphal, Theodore L. DeWeese, Robert Ivkov; Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields. J. Appl. Phys. 15 June 2011; 109 (12): 124904. https://doi.org/10.1063/1.3597820
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