We present a simple and highly versatile protocol for polymer ablation: hard x-ray irradiation makes it possible to rapidly depolymerize hyaluronan hydrogels and fabricate three-dimensional network of microchannels. Photodynamic and photochemical analyses show that x-ray irradiation directly cleaves the polymer backbone and the total dose controls the degradation kinetics. This nonthermal ablation protocol may offer opportunities for processing organic polymers and biological materials.
X-ray ablation of hyaluronan hydrogels: Fabrication of three-dimensional microchannel networks
B. M. Weon, S. Chang, J. Yeom, S. K. Hahn, J. H. Je, Y. Hwu, G. Margaritondo; X-ray ablation of hyaluronan hydrogels: Fabrication of three-dimensional microchannel networks. J. Appl. Phys. 1 September 2009; 106 (5): 053518. https://doi.org/10.1063/1.3213358
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