Photoacoustic (PA) can distinguish oxygenated main chromophores which are hemoglobin and deoxygenated hemoglobin (Hb) in blood by the optical absorption at multiple optical wavelengths. In this study, a noninvasive PA system with a double-ring sensor was used for fixed-point measurement of hemoglobin oxygen saturation continually. The double-ring sensor is an ultrasonic Fresnel zone plate ultrasonic transducer. It has two-zone negative zone plate piezoelectric material pattern with good focusing effect for fixed-point detection of . Three specific optical absorbed wavelengths (760, 805, and 850 nm) of and Hb were employed sequentially to obtain PA signals and calculate the at each blood oxygen level. The capability and accuracy of the system were tested by phantom samples and in vitro blood samples, and the results of the PA detection were in excellent agreement with the data of the control group by the blood-gas analyzer. In in vivo studies, the of the artery and the vein in a rabbit ear were noninvasively detected. Furthermore, changes in the from normal to hypoxia and to hyperoxia due to the changed inhale gas were dynamically recorded by the PA system. The experimental results demonstrate that this PA measurement system has the potential for fixed-point detection and dynamic monitoring of blood oxygen saturation.
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1 July 2009
Research Article|
July 13 2009
Dynamic monitoring of blood oxygen saturation in vivo using double-ring photoacoustic sensor
Guangzhi Yin;
Guangzhi Yin
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics,
South China Normal University
, Guangzhou 510631, China
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Da Xing;
Da Xing
a)
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics,
South China Normal University
, Guangzhou 510631, China
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Sihua Yang
Sihua Yang
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics,
South China Normal University
, Guangzhou 510631, China
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a)
Author to whom correspondence should be addressed. Electronic mail: [email protected]. Tel.: +86-20-85210089. FAX: +86-20-85216052.
J. Appl. Phys. 106, 013109 (2009)
Article history
Received:
March 02 2009
Accepted:
June 05 2009
Citation
Guangzhi Yin, Da Xing, Sihua Yang; Dynamic monitoring of blood oxygen saturation in vivo using double-ring photoacoustic sensor. J. Appl. Phys. 1 July 2009; 106 (1): 013109. https://doi.org/10.1063/1.3160297
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