In this paper, we investigate the development and fluidic analysis of microneedles integrated with painless blood extraction systems that aim to mimic the female mosquito’s blood sampling techniques in certain respects. The microneedles are fabricated by employing the sputtering deposition method. A fluid mechanical analysis is presented toward predicting the transport mechanisms inside the microneedle as dynamically evolving consequences of the resistive forces and the aiding surface tension influences. The theoretical predictions are comprehensively compared to experimental data, and excellent agreements are found for all cases.

1.
M. J.
Madou
,
Fundamentals of Microfabrication
(
CRC
,
Boca Raton, FL
,
2002
).
2.
J. D.
Zahn
,
N. H.
Talbot
,
D.
Liepmann
, and
A. P.
Pisano
,
Biomed. Microdevices
2
,
295
(
2000
).
3.
M. R.
Prausnitz
,
Adv. Drug Delivery Rev.
56
,
581
(
2004
).
4.
S.
Henry
,
D. V.
McAllister
,
M. G.
Allen
, and
M. R.
Prausnitz
,
J. Pharm. Sci.
87
,
922
(
1998
).
5.
W.
Martanto
,
S.
Davis
,
N.
Holiday
,
J.
Wang
, and
H. S.
Gill
,
Pharm. Res.
21
,
947
(
2004
).
6.
D. V.
McAllister
,
P. M.
Wang
,
S. P.
Davis
,
J. -H.
Park
,
M. G.
Allen
, and
M. R.
Prausnitz
,
Proc. Natl. Acad. Sci. U.S.A.
100
,
13755
(
2003
).
7.
Jingkuang
Chen
and
K. D.
Wise
,
IEEE Trans. Biomed. Eng.
44
,
760
(
1997
).
8.
J.
Ji
,
F. E. H.
Tay
,
J.
Miao
, and
C.
Iliescu
,
J. Micromech. Microeng.
16
,
958
(
2006
).
9.
S.
Chakraborty
,
Anal. Chim. Acta
605
,
175
(
2007
).
10.
S.
Das
and
S.
Chakraborty
,
Anal. Chim. Acta
559
,
15
(
2006
).
11.
K.
Tsuchiya
,
N.
Nakanishi
,
Y.
Uetsuji
, and
E.
Nakamachi
,
Biomed. Microdevices
7
,
347
(
2005
).
12.
W.
Huang
,
R. S.
Bhullar
, and
Y. C.
Fung
,
J. Biomech. Eng.
123
,
446
(
2001
).
13.
S.
Chakraborty
,
Lab Chip
5
,
421
(
2005
).
14.
M.
Toner
and
D.
Irimia
,
Annu. Rev. Biomed. Eng.
7
,
77
(
2005
).
15.
T.
Ikeshoji
,
Mosquitoes
(
Tokyo University Press
,
Tokyo
,
1993
) (in Japanese).
16.
M.
Niinomi
,
H.
Fukui
,
Y.
Hattori
,
K.
Kyo
, and
A.
Suzuki
,
Mater. Jpn.
41
,
221
(
2002
).
17.
E. W.
Washburn
,
Phys. Rev.
17
,
273
(
1921
).
18.
C. S.
Yih
,
Fluid Mechanics: A Concise Introduction to the Theory
(
West River
,
Ann Arbor, MI
,
1988
).
19.
C. S.
Yih
,
J. Fluid Mech.
297
,
29
(
1995
).
20.
C. S.
Yih
,
Chin. J. Mech. Eng.
12
,
9
(
1996
).
21.
H. S.
Lew
and
Y. C.
Fung
,
J. Biomech.
3
,
23
(
1970
).
22.
S.
Chakraborty
and
R.
Mittal
,
J. Appl. Phys.
101
,
104901
(
2007
).
23.
R. L.
Hoffman
,
J. Colloid Interface Sci.
50
,
228
(
1975
).
24.
S.
Kalliadasis
and
H. -C.
Chang
,
Phys. Fluids
6
,
12
(
1994
).
25.
J.
Israelachvili
,
Intermolecular Surface Forces
(
Academic
,
New York
,
1992
).
26.
S.
Chakraborty
and
S.
Padhy
,
J. Phys. D
41
,
065502
(
2008
).
27.
S.
Chakraborty
,
Appl. Phys. Lett.
90
,
034108
(
2007
).
28.
S.
Chakraborty
,
Phys. Rev. Lett.
99
,
094504
(
2007
).
29.
S.
Chakraborty
,
T.
Das
, and
S.
Chattoraj
,
J. Appl. Phys.
102
,
104907
(
2007
).
30.
S.
Chakraborty
,
Phys. Rev. Lett.
100
,
097801
(
2008
).
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