The healthy heartbeat is traditionally thought to be regulated according to the classical principle of homeostasis whereby physiologic systems operate to reduce variability and achieve an equilibrium‐like state [Physiol. Rev. 9, 399–431 (1929)]. However, recent studies [Phys. Rev. Lett. 70, 1343–1346 (1993); Fractals in Biology and Medicine (Birkhauser‐Verlag, Basel, 1994), pp. 55–65] reveal that under normal conditions, beat‐to‐beat fluctuations in heart rate display the kind of long‐range correlations typically exhibited by dynamical systems far from equilibrium [Phys. Rev. Lett. 59, 381–384 (1987)]. In contrast, heart rate time series from patients with severe congestive heart failure show a breakdown of this long‐range correlation behavior. We describe a new method—detrended fluctuation analysis (DFA)—for quantifying this correlation property in non‐stationary physiological time series. Application of this technique shows evidence for a crossover phenomenon associated with a change in short and long‐range scaling exponents. This method may be of use in distinguishing healthy from pathologic data sets based on differences in these scaling properties.
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March 1995
Research Article|
March 01 1995
Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series Available to Purchase
C.‐K. Peng;
C.‐K. Peng
Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215
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Shlomo Havlin;
Shlomo Havlin
Department of Physics, Bar Ilan University, Ramat Gan, Israel
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H. Eugene Stanley;
H. Eugene Stanley
Center for Polymer Studies and Department of Physics, Boston, Massachusetts 02215
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Ary L. Goldberger
Ary L. Goldberger
Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
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C.‐K. Peng
Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215
Shlomo Havlin
Department of Physics, Bar Ilan University, Ramat Gan, Israel
H. Eugene Stanley
Center for Polymer Studies and Department of Physics, Boston, Massachusetts 02215
Ary L. Goldberger
Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
Chaos 5, 82–87 (1995)
Article history
Received:
June 28 1994
Accepted:
December 07 1994
Citation
C.‐K. Peng, Shlomo Havlin, H. Eugene Stanley, Ary L. Goldberger; Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos 1 March 1995; 5 (1): 82–87. https://doi.org/10.1063/1.166141
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