In many biological systems, information is transferred by hormonal ligands, and it is assumed that these hormonal signals encode developmental and regulatory programs in mammalian organisms. In contrast to the dogma of endocrine homeostasis, it could be shown that the biological information in hormonal networks is not only present as a constant hormone concentration in the circulation pool. Recently, it has become apparent that hormone pulses contribute to this hormonal pool, which modulates the responsiveness of receptors within the cell membrane by regulation of the receptor synthesis, movement within the membrane layer, coupling to signal transduction proteins and internalization. Phase space analysis of dynamic parathyroid hormone (PTH) secretion allowed the definition of a (in comparison to normal subjects) relatively quiet ‘‘low dynamic’’ secretory pattern in osteoporosis, and a ‘‘high dynamic’’ state in hyperparathyroidism. We now investigate whether this pulsatile secretion of PTH in healthy men exhibits characteristics of nonlinear determinism. Our findings suggest that this is conceivable, although on the basis of presently available data and techniques, no proof can be established. Nevertheless, pulsatile secretion of PTH might be a first example of nonlinear deterministic dynamics in an apparently irregular hormonal rhythm in human physiology.
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March 1995
Research Article|
March 01 1995
Nonlinear dynamics in pulsatile secretion of parathyroid hormone in normal human subjects Available to Purchase
Klaus Prank;
Klaus Prank
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
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Heio Harms;
Heio Harms
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
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Georg Brabant;
Georg Brabant
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
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Rolf‐Dieter Hesch;
Rolf‐Dieter Hesch
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
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Matthias Dämmig;
Matthias Dämmig
Institut für Quantenoptik, Universität Hannover, Welfengarten 1, D‐30167 Hannover, Germany
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Fedor Mitschke
Fedor Mitschke
Institut für Quantenoptik, Universität Hannover, Welfengarten 1, D‐30167 Hannover, Germany
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Klaus Prank
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
Heio Harms
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
Georg Brabant
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
Rolf‐Dieter Hesch
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty‐Gutschow‐Str. 8, D‐30625 Hannover, Germany
Matthias Dämmig
Institut für Quantenoptik, Universität Hannover, Welfengarten 1, D‐30167 Hannover, Germany
Fedor Mitschke
Institut für Quantenoptik, Universität Hannover, Welfengarten 1, D‐30167 Hannover, Germany
Chaos 5, 76–81 (1995)
Article history
Received:
May 10 1994
Accepted:
August 08 1994
Citation
Klaus Prank, Heio Harms, Georg Brabant, Rolf‐Dieter Hesch, Matthias Dämmig, Fedor Mitschke; Nonlinear dynamics in pulsatile secretion of parathyroid hormone in normal human subjects. Chaos 1 March 1995; 5 (1): 76–81. https://doi.org/10.1063/1.166089
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