As the potential for a treatment of Duchenne muscular dystrophy (DMD) grows, the need for methods for the early diagnosis of DMD becomes more and more important. Clinical experiences suggest that children with DMD will show some lack of motor ability in the early stage when compared with children at the same age, especially in balance and coordination abilities. Is it possible to quantify the coordination differences between DMD and typically developing (TD) children to achieve the goal of screening for DMD diseases? In this study, we introduced a Local Manifold Structure Mapping approach in phase space and extracted a novel index, relative coupling coefficient (RCC), from gait pattern signals, which were acquired by wearable accelerometers to evaluate the coordination of children with DMD during a walking task. Furthermore, we compared the RCC of 100 children with DMD and 100 TD children in four different age groups and verified the feasibility and reliability of the proposed indices to distinguish children with TD from DMD. T-test results show that, for all age groups, children of the same age with DMD and TD show significant differences in RCC (p < 0.001). Moreover, RCC comprehensively reflects that the coordination ability of DMD patients under walking tasks gradually decreases with age, which is consistent with clinical experience. As a functional biomarker extracted in the phase space of the gait data, the proposed coupling degree index RCC could sensitively distinguish between DMD and TD children at the same age and provide alternative insights and potentially valuable tools for the screening of DMD.
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February 2020
Research Article|
February 11 2020
Quantitative coordination evaluation for screening children with Duchenne muscular dystrophy
Jian An;
Jian An
1
Academy of Advanced Interdisciplinary Studies, Peking University
, Beijing 100871, China
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Zhiying Xie;
Zhiying Xie
2
Department of Neurology, Peking University First Hospital
, Beijing 100034, China
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Fan Jia;
Fan Jia
1
Academy of Advanced Interdisciplinary Studies, Peking University
, Beijing 100871, China
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Zhaoxia Wang;
Zhaoxia Wang
2
Department of Neurology, Peking University First Hospital
, Beijing 100034, China
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Yun Yuan;
Yun Yuan
a)
2
Department of Neurology, Peking University First Hospital
, Beijing 100034, China
a)Authors to whom correspondence should be addressed: yuanyun2002@sohu.com, Tel.: 86-10-83572588, Fax: 86-10-66176450 and zhangjue@pku.edu.cn, Tel.: 86-10-62755036, Fax: 86-10-62753562
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Jue Zhang;
Jue Zhang
a)
1
Academy of Advanced Interdisciplinary Studies, Peking University
, Beijing 100871, China
3
College of Engineering, Peking University
, Beijing 100871, China
a)Authors to whom correspondence should be addressed: yuanyun2002@sohu.com, Tel.: 86-10-83572588, Fax: 86-10-66176450 and zhangjue@pku.edu.cn, Tel.: 86-10-62755036, Fax: 86-10-62753562
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Jing Fang
Jing Fang
1
Academy of Advanced Interdisciplinary Studies, Peking University
, Beijing 100871, China
3
College of Engineering, Peking University
, Beijing 100871, China
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a)Authors to whom correspondence should be addressed: yuanyun2002@sohu.com, Tel.: 86-10-83572588, Fax: 86-10-66176450 and zhangjue@pku.edu.cn, Tel.: 86-10-62755036, Fax: 86-10-62753562
Chaos 30, 023116 (2020)
Article history
Received:
September 02 2019
Accepted:
January 08 2020
Citation
Jian An, Zhiying Xie, Fan Jia, Zhaoxia Wang, Yun Yuan, Jue Zhang, Jing Fang; Quantitative coordination evaluation for screening children with Duchenne muscular dystrophy. Chaos 1 February 2020; 30 (2): 023116. https://doi.org/10.1063/1.5126116
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