COVID-19 has forced quarantine measures in several countries across the world. These measures have proven to be effective in significantly reducing the prevalence of the virus. To date, no effective treatment or vaccine is available. In the effort of preserving both public health and the economical and social textures, France and Italy governments have partially released lockdown measures. Here, we extrapolate the long-term behavior of the epidemic in both countries using a susceptible-exposed-infected-recovered model, where parameters are stochastically perturbed with a lognormal distribution to handle the uncertainty in the estimates of COVID-19 prevalence and to simulate the presence of super-spreaders. Our results suggest that uncertainties in both parameters and initial conditions rapidly propagate in the model and can result in different outcomes of the epidemic leading or not to a second wave of infections. Furthermore, the presence of super-spreaders adds instability to the dynamics, making the control of the epidemic more difficult. Using actual knowledge, asymptotic estimates of COVID-19 prevalence can fluctuate of the order of 10×106 units in both countries.

1.
E. R.
Gaunt
,
A.
Hardie
,
E. C.
Claas
,
P.
Simmonds
, and
K. E.
Templeton
, “
Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, Nl63, and OC43 detected over 3 years using a novel multiplex real-time PCR method
,”
J. Clin. Microbiol.
48
,
2940
2947
(
2010
).
2.
J.
Wu
,
W.
Cai
,
D.
Watkins
, and
J.
Glanz
, “How the virus got out,” The New York Times, 2020.
3.
WHO, Coronavirus disease 2019 (COVID-19): Situation report, 2020, p. 51.
4.
C.
COVID
and
R.
Team
, “
Severe outcomes among patients with coronavirus disease 2019 (COVID-19), United States, February 12–March 16, 2020
,”
MMWR Morb. Mortal Wkly Rep.
69
,
343
346
(
2020
).
5.
Y.-Y.
Zheng
,
Y.-T.
Ma
,
J.-Y.
Zhang
, and
X.
Xie
, “
COVID-19 and the cardiovascular system
,”
Nat. Rev. Cardiol.
17
,
259
260
(
2020
).
6.
C.
Huang
,
Y.
Wang
,
X.
Li
,
L.
Ren
,
J.
Zhao
,
Y.
Hu
,
L.
Zhang
,
G.
Fan
,
J.
Xu
,
X.
Gu
et al., “
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
,”
The Lancet
395
,
497
506
(
2020
).
7.
M.
Cascella
,
M.
Rajnik
,
A.
Cuomo
,
S. C.
Dulebohn
, and
R.
Di Napoli
, “Features, evaluation and treatment coronavirus (COVID-19),” in Statpearls [Internet] (StatPearls Publishing, 2020).
8.
R. M.
Anderson
,
H.
Heesterbeek
,
D.
Klinkenberg
, and
T. D.
Hollingsworth
, “
How will country-based mitigation measures influence the course of the COVID-19 epidemic?
,”
The Lancet
395
,
931
934
(
2020
).
9.
M.
Chinazzi
,
J. T.
Davis
,
M.
Ajelli
,
C.
Gioannini
,
M.
Litvinova
,
S.
Merler
,
A.
Pastore y Piontti
,
K.
Mu
,
L.
Rossi
,
K.
Sun
,
C.
Viboud
,
X.
Xiong
,
H.
Yu
,
M. E.
Halloran
,
I. M.
Longini
, and
A.
Vespignani
, “
The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak
,”
Science
368
,
395
400
(
2020
).
10.
H.-Y.
Yuan
,
G.
Han
,
H.
Yuan
,
S.
Pfeiffer
,
A.
Mao
,
L.
Wu
, and
D.
Pfeiffer
, “
The importance of the timing of quarantine measures before symptom onset to prevent COVID-19 outbreaks—Illustrated by Hong Kong’s intervention model
,”
medRxiv
2020.05.03.20089482 (
2020
).
11.
R. H.
Mena
,
J. X.
Velasco-Hernandez
,
N. B.
Mantilla-Beniers
,
G. A.
Carranco-Sapiéns
,
L.
Benet
,
D.
Boyer
, and
I. P.
Castillo
, “Using the posterior predictive distribution to analyse epidemic models: COVID-19 in Mexico city,” arXiv:2005.02294 (2020).
12.
S.
Khajanchi
and
K.
Sarkar
, “
Forecasting the daily and cumulative number of cases for the COVID-19 pandemic in India
,”
Chaos
30
,
071101
(
2020
).
13.
K.
Sarkar
,
S.
Khajanchi
, and
J. J.
Nieto
, “
Modeling and forecasting the COVID-19 pandemic in India
,”
Chaos Soliton. Fract.
139
,
110049
(
2020
).
14.
N.
Fernandes
, “Economic effects of coronavirus outbreak (COVID-19) on the world economy,” available at SSRN 3557504 (2020).
15.
O.
Coibion
,
Y.
Gorodnichenko
, and
M.
Weber
, “Labor markets during the COVID-19 crisis: A preliminary view,” Technical Report, National Bureau of Economic Research, 2020.
16.
N.
Cellini
,
N.
Canale
,
G.
Mioni
, and
S.
Costa
, “
Changes in sleep pattern, sense of time and digital media use during COVID-19 lockdown in Italy
,”
J. Sleep Res.
29
,
e13074
(
2020
).
17.
H. A.
Rothan
and
S. N.
Byrareddy
, “
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak
,”
J. Autoimmun.
109
,
102433
(
2020
).
18.
N.
Chintalapudi
,
G.
Battineni
, and
F.
Amenta
, “
COVID-19 disease outbreak forecasting of registered and recovered cases after sixty day lockdown in Italy: A data driven model approach
,”
J. Microbiol. Immunol. Infect.
53
,
396
403
(
2020
).
19.
M.
Gatto
,
E.
Bertuzzo
,
L.
Mari
,
S.
Miccoli
,
L.
Carraro
,
R.
Casagrandi
, and
A.
Rinaldo
, “
Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures
,”
Proc. Natl. Acad. Sci. U.S.A.
117
,
10484
10491
(
2020
).
20.
J.
Roux
,
C.
Massonnaud
, and
P.
Crépey
, “
COVID-19: One-month impact of the French lockdown on the epidemic burden
,”
medRxiv
2020.04.22.20075705 (
2020
).
21.
L.
Di Domenico
,
G.
Pullano
,
C. E.
Sabbatini
,
P.-Y.
Boëlle
, and
V.
Colizza
, “
Expected impact of lockdown in île-de-France and possible exit strategies
,”
medRxiv
2020.04.13.20063933 (
2020
).
22.
B.
Ghoshal
and
A.
Tucker
, “Estimating uncertainty and interpretability in deep learning for coronavirus (COVID-19) detection,” arXiv:2003.10769 (2020).
23.
T.
Hale
,
A.
Petherick
,
T.
Phillips
, and
S.
Webster
, “Variation in government responses to COVID-19,” Blavatnik School of Government Working Paper 31, 2020.
24.
R.
Li
,
S.
Pei
,
B.
Chen
,
Y.
Song
,
T.
Zhang
,
W.
Yang
, and
J.
Shaman
, “
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)
,”
Science
368
,
489
493
(
2020
).
25.
R.
Nunes-Vaz
, “
Visualising the doubling time of COVID-19 allows comparison of the success of containment measures
,”
Global Biosecur.
1
,
1
4
(
2020
).
26.
A. N.
Desai
,
M. U.
Kraemer
,
S.
Bhatia
,
A.
Cori
,
P.
Nouvellet
,
M.
Herringer
,
E. L.
Cohn
,
M.
Carrion
,
J. S.
Brownstein
,
L. C.
Madoff
et al., “
Real-time epidemic forecasting: Challenges and opportunities
,”
Health Secur.
17
,
268
275
(
2019
).
27.
D.
Faranda
,
I. P.
Castillo
,
O.
Hulme
,
A.
Jezequel
,
J. S. W.
Lamb
,
Y.
Sato
, and
E. L.
Thompson
, “
Asymptotic estimates of SARS-CoV-2 infection counts and their sensitivity to stochastic perturbation
,”
Chaos
30
,
051107
(
2020
).
28.
J. O.
Lloyd-Smith
,
S. J.
Schreiber
,
P. E.
Kopp
, and
W. M.
Getz
, “
Superspreading and the effect of individual variation on disease emergence
,”
Nature
438
,
355
359
(
2005
).
29.
F.
Brauer
, “Compartmental models in epidemiology,” in Mathematical Epidemiology (Springer, 2008), pp. 19–79.
30.
T.
Alberti
and
D.
Faranda
, “
On the uncertainty of real-time predictions of epidemic growths: A COVID-19 case study for China and Italy
,”
Commun. Nonlinear Sci. Numer. Simul.
90
,
105372
(
2020
).
31.
G.
Consolini
and
M.
Materassi
, “
A stretched logistic equation for pandemic spreading
,”
Chaos Soliton. Fract.
140
,
110113
(
2020
).
32.
F.
D’Emilio
and
N.
Winfield
, “Italy blasts virus panic as it eyes new testing criteria,” ABC News, 2020.
33.
K.
Arin
, “Drive-thru clinics, drones: Korea’s new weapons in virus fight,” The Korea Herald, 2020.
34.
P. P.
AGI
, “Come vanno letti i dati sul coronavirus in Italia,” AGI Agenzia Italia, 2020.
35.
L.
Ferrari
,
G.
Gerardi
,
G.
Manzi
,
A.
Micheletti
,
F.
Nicolussi
, and
S.
Salini
, “Modelling provincial COVID-19 epidemic data in Italy using an adjusted time-dependent SIRD model,” arXiv:2005.12170 (2020).
36.
J.
Cohen
and
K.
Kupferschmidt
, “
Countries test tactics in ‘war’ against COVID-19
,”
Science
367
(
6484
),
1287
1288
(
2020
).
37.
J. H.
Tanne
,
E.
Hayasaki
,
M.
Zastrow
,
P.
Pulla
,
P.
Smith
, and
A. G.
Rada
, “
Covid-19: How doctors and healthcare systems are tackling coronavirus worldwide
,”
BMJ
368
,
m1090
(
2020
).
38.
P.
Kellam
and
W.
Barclay
, “
The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection
,”
J. Gen. Virol.
101
,
jgv001439
(
2020
).
39.
A. T.
Xiao
,
C.
Gao
, and
S.
Zhang
, “
Profile of specific antibodies to SARS-CoV-2: The first report
,”
J. Infect.
81
,
147
178
(
2020
).
40.
A.
Grifoni
,
D.
Weiskopf
,
S. I.
Ramirez
,
J.
Mateus
,
J. M.
Dan
,
C. R.
Moderbacher
,
S. A.
Rawlings
,
A.
Sutherland
,
L.
Premkumar
,
R. S.
Jadi
et al., “
Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
,”
Cell
181
,
1489
1501
(
2020
).
41.
L.
Ni
,
F.
Ye
,
M.-L.
Cheng
,
Y.
Feng
,
Y.-Q.
Deng
,
H.
Zhao
,
P.
Wei
,
J.
Ge
,
M.
Gou
,
X.
Li
et al., “
Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals
,”
Immunity
52
,
971
977
(
2020
).
42.
S. M.
Kissler
,
C.
Tedijanto
,
E.
Goldstein
,
Y. H.
Grad
, and
M.
Lipsitch
, “
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
,”
Science
368
,
860
868
(
2020
).
43.
J. T.
Wu
,
K.
Leung
, and
G. M.
Leung
, “
Nowcasting and forecasting the potential domestic and international spread of the 2019-NCOV outbreak originating in Wuhan, China: A modelling study
,”
Lancet
395
,
689
697
(
2020
).
44.
L.
Peng
,
W.
Yang
,
D.
Zhang
,
C.
Zhuge
, and
L.
Hong
, “Epidemic analysis of COVID-19 in China by dynamical modeling,” arXiv:2002.06563 (2020).
45.
S. A.
Lauer
,
K. H.
Grantz
,
Q.
Bi
,
F. K.
Jones
,
Q.
Zheng
,
H. R.
Meredith
,
A. S.
Azman
,
N. G.
Reich
, and
J.
Lessler
, “
The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application
,”
Ann. Intern. Med.
172
,
577
582
(
2020
).
46.
E.
Lavezzo
,
E.
Franchin
,
C.
Ciavarella
,
G.
Cuomo-Dannenburg
,
L.
Barzon
,
C.
Del Vecchio
,
L.
Rossi
,
R.
Manganelli
,
A.
Loregian
,
N.
Navarin
,
D.
Abate
,
M.
Sciro
,
S.
Merigliano
,
E.
De Canale
,
M. C.
Vanuzzo
,
V.
Besutti
,
F.
Saluzzo
,
F.
Onelia
,
M.
Pacenti
,
S. G.
Parisi
,
G.
Carretta
,
D.
Donato
,
L.
Flor
,
S.
Cocchio
,
G.
Masi
,
A.
Sperduti
,
L.
Cattarino
,
R.
Salvador
,
M.
Nicoletti
,
F.
Caldart
,
G.
Castelli
,
E.
Nieddu
,
B.
Labella
,
L.
Fava
,
M.
Drigo
,
K. A. M.
Gaythorpe
,
Imperial College COVID-19 Response Team
,
A. R.
Brazzale
,
S.
Toppo
,
M.
Trevisan
,
V.
Baldo
,
C. A.
Donnelly
,
N. M.
Ferguson
,
I.
Dorigatti
, and
A.
Crisanti
, “
Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
,”
Nature
584
(
7821
),
425
429
(
2020
).
47.
L. F.
Olsen
and
W. M.
Schaffer
, “
Chaos versus noisy periodicity: Alternative hypotheses for childhood epidemic
,”
Science
249
,
499
504
(
1990
).
48.
H.
Andersson
and
T.
Britton
,
Stochastic Epidemic Models and Their Statistical Analysis
(
Springer Science & Business Media
,
2012
), Vol. 151.
49.
J.
Dureau
,
K.
Kalogeropoulos
, and
M.
Baguelin
, “
Capturing the time-varying drivers of an epidemic using stochastic dynamical systems
,”
Biostatistics
14
,
541
555
(
2013
).
50.
J. A.
Polonsky
,
A.
Baidjoe
,
Z. N.
Kamvar
,
A.
Cori
,
K.
Durski
,
W. J.
Edmunds
,
R. M.
Eggo
,
S.
Funk
,
L.
Kaiser
,
P.
Keating
et al., “
Outbreak analytics: A developing data science for informing the response to emerging pathogens
,”
Philos. Trans. R. Soc. B
374
,
20180276
(
2019
).
51.
G.
Viceconte
and
N.
Petrosillo
, “
COVID-19 R0: Magic number or conundrum?
,”
Infect. Dis. Rep.
12
(
1
),
8516
(
2020
).
52.
I.
Kashnitsky
, “
COVID-19 in unequally ageing European regions
,”
World Dev.
136
,
105170
(
2020
).
53.
D.
Faranda
and
S.
Vaienti
, “
Extreme value laws for dynamical systems under observational noise
,”
Physica D
280
,
86
94
(
2014
).
54.
D.
Faranda
,
Y.
Sato
,
B.
Saint-Michel
,
C.
Wiertel
,
V.
Padilla
,
B.
Dubrulle
, and
F.
Daviaud
, “
Stochastic chaos in a turbulent swirling flow
,”
Phys. Rev. Lett.
119
,
014502
(
2017
).
55.
J.
Zhang
,
M.
Litvinova
,
W.
Wang
,
Y.
Wang
,
X.
Deng
,
X.
Chen
,
M.
Li
,
W.
Zheng
,
L.
Yi
,
X.
Chen
et al., “
Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: A descriptive and modelling study
,”
Lancet Infect. Dis.
20
,
793
802
(
2020
).
56.
J. A.
Al-Tawfiq
and
A. J.
Rodriguez-Morales
, “
Super-spreading events and contribution to transmission of MERS, SARS, and COVID-19
,”
J. Hospital Infection
105
(
2
),
111
112
(
2020
).
57.
A.
Deslandes
,
V.
Berti
,
Y.
Tandjaoui-Lambotte
,
C.
Alloui
,
E.
Carbonnelle
,
J.
Zahar
,
S.
Brichler
, and
Y.
Cohen
, “
SARS-CoV-2 was already spreading in France in late December 2019
,”
Int. J. Antimicrob. Agents
55
,
106006
(
2020
).
58.
G.
Pullano
,
E.
Valdano
,
N.
Scarpa
,
S.
Rubrichi
, and
V.
Colizza
, “
Population mobility reductions during COVID-19 epidemic in France under lockdown
,”
medRxiv
2020.05.29.20097097 (
2020
).
59.
H.
Salje
,
C. T.
Kiem
,
N.
Lefrancq
,
N.
Courtejoie
,
P.
Bosetti
,
J.
Paireau
,
A.
Andronico
,
N.
Hoze
,
J.
Richet
,
C.-L.
Dubost
et al., “
Estimating the burden of SARS-CoV-2 in France
,”
Science
369
,
208
211
(
2020
).
60.
H.
Salje
,
C.
Tran Kiem
,
N.
Lefrancq
,
N.
Courtejoie
,
P.
Bosetti
,
J.
Paireau
,
A.
Andronico
,
N.
Hozé
,
J.
Richet
,
C.-L.
Dubost
,
Y.
Le Strat
,
J.
Lessler
,
D.
Levy-Bruhl
,
A.
Fontanet
,
L.
Opatowski
,
P.-Y.
Boelle
, and
S.
Cauchemez
, “
Estimating the burden of SARS-CoV-2 in France
,”
Science
369
,
208
211
(
2020
).
61.
M.
Maleki
,
M. R.
Mahmoudi
,
D.
Wraith
, and
K.-H.
Pho
, “
Time series modelling to forecast the confirmed and recovered cases of COVID-19
,”
Travel Med. Infect. Dis.
37
,
101742
(
2020
).
62.
“Coronavirus milano, la 41enne con la febbre il 22 dicembre: ‘ora hanno trovato gli anticorpi al COVID’,” Corriere della Sera (April 20, 2020).
63.
S.
Flaxman
,
S.
Mishra
,
A.
Gandy
,
H.
Unwin
,
H.
Coupland
,
T.
Mellan
,
H.
Zhu
,
T.
Berah
,
J.
Eaton
,
P.
Perez Guzman
, and
N.
Schmit
, “
Report 13: The impact of non-pharmaceutical interventions on COVID-19 in 11 European countries
,”
Imperial College report
(
2020
).
64.
G.
De Natale
,
V.
Ricciardi
,
G.
De Luca
,
D.
De Natale
,
G.
Di Meglio
,
A.
Ferragamo
,
V.
Marchitelli
,
A.
Piccolo
,
A.
Scala
,
R.
Somma
,
E.
Spina
, and
C.
Troise
, “
The COVID-19 infection in Italy: A statistical study of an abnormally severe disease
,”
J. Clin. Med.
9
,
1564
(
2020
).
65.
L.
Wang
and
X.
Li
, “
Spatial epidemiology of networked metapopulation: An overview
,”
Chin. Sci. Bull.
59
,
3511
3522
(
2014
).
66.
Q.-X.
Long
,
B.-Z.
Liu
,
H.-J.
Deng
,
G.-C.
Wu
,
K.
Deng
,
Y.-K.
Chen
,
P.
Liao
,
J.-F.
Qiu
,
Y.
Lin
,
X.-F.
Cai
et al., “
Antibody responses to SARS-CoV-2 in patients with COVID-19
,”
Nat. Med.
26
(
6
),
845
848
(
2020
).
67.
Y.
Liu
,
R. M.
Eggo
, and
A. J.
Kucharski
, “
Secondary attack rate and superspreading events for SARS-CoV-2
,”
Lancet
395
,
e47
(
2020
).
68.
A.
d’Onofrio
,
P.
Manfredi
, and
E.
Salinelli
, “
Vaccinating behaviour, information, and the dynamics of sir vaccine preventable diseases
,”
Theor. Popul. Biol.
71
,
301
317
(
2007
).
69.
S.
Khajanchi
,
K.
Sarkar
,
J.
Mondal
, and
M.
Perc
, “Dynamics of the COVID-19 pandemic in India,” arXiv:2005.06286 (2020).
70.
M.
Renardy
,
M.
Eisenberg
, and
D.
Kirschner
, “
Predicting the second wave of COVID-19 in Washtenaw county, MI
,”
J. Theor. Biol.
507
,
110461
(
2020
).
71.
B.
Ghanbari
, “
On forecasting the spread of the COVID-19 in Iran: The second wave
,”
Chaos Soliton. Fract.
140
,
110176
(
2020
).
72.
J.
Daunizeau
,
R.
Moran
,
J.
Brochard
,
J.
Mattout
,
R.
Frackowiak
, and
K.
Friston
, “
Modelling lockdown-induced secondary COVID waves in France
,”
medRxiv
2020.06.24.20139444 (
2020
).
73.
E.
Dong
,
H.
Du
, and
L.
Gardner
, “
An interactive web-based dashboard to track COVID-19 in real time
,”
Lancet Infect Dis.
(
published online 2020
).
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