We assess electrical brain dynamics before, during, and after 100 human epileptic seizures with different anatomical onset locations by statistical and spectral properties of functionally defined networks. We observe a concave-like temporal evolution of characteristic path length and cluster coefficient indicative of a movement from a more random toward a more regular and then back toward a more random functional topology. Surprisingly, synchronizability was significantly decreased during the seizure state but increased already prior to seizure end. Our findings underline the high relevance of studying complex systems from the viewpoint of complex networks, which may help to gain deeper insights into the complicated dynamics underlying epileptic seizures.
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September 2008
Research Article|
August 15 2008
Evolving functional network properties and synchronizability during human epileptic seizures
Kaspar A. Schindler;
Kaspar A. Schindler
a)
1Department of Epileptology,
University of Bonn
, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
2Department of Neurology, Inselspital,
Bern University Hospital
and University of Bern, Switzerland
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Stephan Bialonski;
Stephan Bialonski
1Department of Epileptology,
University of Bonn
, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
3Helmholtz-Institute for Radiation and Nuclear Physics,
University of Bonn
, Nussallee 14-16, 53115 Bonn, Germany
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Marie-Therese Horstmann;
Marie-Therese Horstmann
1Department of Epileptology,
University of Bonn
, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
3Helmholtz-Institute for Radiation and Nuclear Physics,
University of Bonn
, Nussallee 14-16, 53115 Bonn, Germany
4Interdisciplinary Center for Complex Systems,
University of Bonn
, Römerstrasse 164, 53117 Bonn, Germany
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Christian E. Elger;
Christian E. Elger
1Department of Epileptology,
University of Bonn
, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
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Klaus Lehnertz
Klaus Lehnertz
b)
1Department of Epileptology,
University of Bonn
, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
3Helmholtz-Institute for Radiation and Nuclear Physics,
University of Bonn
, Nussallee 14-16, 53115 Bonn, Germany
4Interdisciplinary Center for Complex Systems,
University of Bonn
, Römerstrasse 164, 53117 Bonn, Germany
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Chaos 18, 033119 (2008)
Article history
Received:
May 21 2008
Accepted:
July 10 2008
Citation
Kaspar A. Schindler, Stephan Bialonski, Marie-Therese Horstmann, Christian E. Elger, Klaus Lehnertz; Evolving functional network properties and synchronizability during human epileptic seizures. Chaos 1 September 2008; 18 (3): 033119. https://doi.org/10.1063/1.2966112
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