Heart rate oscillates on several different time scales and has long‐term variability in the form of 1/f noise. The physiological control of heart rate is briefly reviewed, and several typical patterns of heart rate variability, in health and sickness, are described. Considered briefly are some possible dynamical mechanisms for heart rate variability.
REFERENCES
1.
A. L.
Goldberger
, D. R.
Rigney
, and B. J.
West
, “Chaos and fractals in human physiology
,” Sci. Am.
262
, 42
–49
(feb. 1990
).2.
R. I.
Kitney
, S.
Byrne
, M. E.
Edwards
, P. J.
Watkins
, and V. C.
Roberts
, “Heart rate variability in the assessment of autonomic diabetic neuropathy
,” Automedica
4
, 155
–167
(1982
).3.
M.
Lishner
, S.
Akselrod
, V.
Mor Avi
, O.
Oz
, M.
Divon
, and M.
Ravid
, “Spectral analysis of heart rate fluctuations. A noninvasive, sensitive method for the early diagnosis of autonomic neuropathy in diabetes mellitus
,” J. Auton. Nerv. Syst.
19
, 119
–125
(1987
).4.
R. E.
Kleiger
, J. P.
Miller
, J. T.
Bigger
, A. J.
Moss
, and the Multicenter Post-Infarction Research Group, “Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
,” Am. J. Cardiol.
59
, 256
–262
(1987
).5.
R. M. Berne and M. N. Levy, Cardiovascular Physiology (Mosby, St. Louis, 1986), 5th ed.
6.
The autonomic nervous system is the “involuntary” part of the nervous system.
7.
R. F. Rushmer, Cardiovascular Dynamics (Saunders, Philadelphia, 1961), 2nd ed., p. 56, Fig. 3;
C.
Borst
and J. M.
Karemaker
, “Time delays in the human baroreceptor reflex
,” J. Auton. Nerv. Syst.
9
, 399
–409
(1983
).8.
A. C.
Selman
, A. H.
McDonald
, R. I.
Kitney
, and D. A.
Linkens
, “The interaction between heart rate and respiration: Part 1—experimental studies in man
,” Automedica
4
, 131
–139
(1982
).9.
M. Courtemanche, L. Glass, M. D. Rosengarten, and A. L. Goldberger, “Beyond pure parasystole: promises and problems in modeling complex arrhythmias,” Am. J. Physiol. (Heart Ore. Physiol. 26), H693-H706 (1989).
10.
R. G. Mark and G. B. Moody, “Arrhythmia analysis, automated,” in Encyclopedia of Medical Devices and Instrumentation (Wiley, New York, 1989), Vol. 1.
11.
M. L.
Ahlstrom
and W. J.
Tompkins
, “Automated high-speed analysis of Holter tapes with microcomputers
,” IEEE Trans. Biomed. Eng.
BME-30
, 651
–657
(1983
).12.
R. D.
Berger
, S.
Akselrod
, D.
Gordon
, and R. J.
Cohen
, “An efficient algorithm for spectral analysis of heart rate variability
,” IEEE Trans. Biomed. Eng.
BME-33
, 900
–904
(1986
).13.
W. J. M.
Rushesky
, D.
Fader
, O.
Schmitt
, and V.
Gilbertsen
, “The respiratory sinus arrhythmia: a measure of cardiac age
,” Science
224
, 1001
–1004
(1984
).14.
A. D.
O’Brien
, P.
O’Hare
, and R. J. M.
Corral
, “Heart rate variability in normal subjects: effects of age and the derivation of normal ranges for tests of autonomic function
,” Br. Heart. J.
55
, 348
–354
(1984
).15.
S.
Akselrod
, D.
Gordon
, F. A.
Ubel
, D. C.
Shannon
, A. C.
Barger
, and R. J.
Cohen
, “Power spectrum analysis of heart rate fluctuations: A quantitative probe of beat-to-beat cardiovascular control
,” Science
213
, 220
–222
(1981
).16.
B.
Pomeranz
, R. J. B.
Macaulay
, M. A.
Caudil
, I.
Kutz
, D. C.
Shannon
, R. J.
Cohen
, and H.
Benson
, “Assessment of autonomic function in humans by heart rate spectral analysis
,” Am. J. Physiol.
248
, H151
–H153
(1985
).17.
R. W.
DeBoer
, J. M.
Karemaker
, and J.
Strackee
, “Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model
,” Am. J. Physiol.
253
, 680
–689
(1987
).18.
R. D. Berger, J. P. Saul, P. Albrechtt S. P. Stein, and R. J. Cohen, “Respiratory effects on arterial pressure:, a novel signal analysis approach,” Proceedings, IEEE Engineering in Medicine and Biology Society, New Orleans, 533–534 (1988).
19.
S.
Akselrod
, D.
Gordon
, J. B.
Madwed
, N. C.
Snidman
, D. C.
Shannon
, and R. J.
Cohen
, “Hemodynamic regulation: investigation by spectral analysis
,” Am. J. Physiol.
249
, H867
-H875
(1985
).20.
Y.
Arai
, J. P.
Saul
, P.
Albrecht
, L. H.
Hartley
, L. S.
Lilly
, R. J.
Cohen
, and W. S.
Colucci
, “Modulation of cardiac autonomic activity during and immediately after exercise
,” Am. J. Physiol.
256
(Heart Circ. Phys. 25),H132
-H141
(1989
).21.
J. B. Madwed, K. E. Sands, J. P. Saul, and R. J. Cohen, “Spectral analysis of beat-to-beat variability in heart rate and arterial blood pressure during hemorrhage and aortic construction,” in Neural Mechanisms and Cardiovascular Disease, edited by B. Lown et al., (Liviana, Padua, Italy, 1986), pp. 291–302.
22.
D. P.
Giddens
and R. I.
Kitney
, “Neonatal heart rate variability and its relation to respiration
,” J. Theoret. Biol.
113
, 759
–780
(1985
).23.
R. D.
Berger
, J. P.
Saul
, and R. J.
Cohen
, “Transfer function analysis of autonomic regulation. I. The canine atrial response
,” Am. J. Physiol.
256
(Heart Circ. Physiol. 25),H142
-H152
(1989
).24.
J. P.
Saul
, Y.
Arai
, R. D.
Berger
, L. S.
Lilly
, W. S.
Colucci
, and R. J.
Cohen
, “Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis
,” Am. J. Cardiol.
61
, 1292
-1299
(1988
).25.
M. H.
Kryger
and T.
Millar
, “Cheyne Stokes Respiration: Stability of Interacting Systems in Heart Failure
,” Chaos
1
, 265
–269
(1991
).26.
M.
Kobayashi
and T.
Musha
, “1//f fluctuation of heartbeat period
,” IEEE Trans. Biomed. Eng.
BME-29
, 456
–457
(1982
).27.
A. C.
Guyton
, “Blood pressure control—special role of the kidneys and body fluids
,” Science
252
, 1813
–1816
(1991
).28.
G. M.
DeFerrari
and P. J.
Schwartz
, “Automatic nervous system and arrhythmias
,” Ann. NY Acad. Sci.
601
, 247
–262
(1990
).29.
F.
Lombardi
, G.
Sandrone
, S.
Pernpruner
, R.
Sala
, M.
Garimoldi
, S.
Cerutti
, G.
Baselli
, M.
Pagani
, and A.
Malliani
, “Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction
,” Am. J. Cardiol.
60
, 1239
–1245
(1987
).30.
G. A.
Myers
, G. J.
Martin
, N. M.
Magid
, P. S.
Bennet
, J. W.
Schaad
, J. S.
Weiss
, M.
Lesch
, and D. H.
Singer
, “Power spectral analysis of heart rate variability in sudden cardiac death: comparison to other methods
,” IEEE Trans. Biomed. Eng.
BME-33
, 1149
–1156
(1986
).31.
G.
Casolo
, E.
Balli
, T.
Tamara
, J.
Amuhasi
, and C.
Gori
, “Decreased spontaneous heart rate variability in congestive heart failure
,” Am. J. Cardiol.
64
, 1162
–1167
(1989
).32.
D.
Alexopouos
, S.
Yusuf
, J. A.
Johnston
, J.
Bostock
, P.
Sleight
, and M. H.
Yacoub
, “The 24-hour heart rate behavior in long-term survivors of cardiac transplantation
,” Am. J. Cardiol.
61
, 880
–884
(1988
).33.
K. E. F.
Sands
, M. L.
Appel
, L. S.
Lilly
, F. J.
Schoen
, G. H.
Mudge
, and R. J.
Cohen
, “Assessment of heart rate variability in human cardiac transplant recipients using power spectrum analysis
,” Circulation
79
, 76
–82
(1989
).34.
A. L.
Goldberger
, L. J.
Findley
, M. R.
Blackburn
, and A. J.
Mandell
, “Nonlinear dynamics in heart failure: implications of long-wavelength cardiopulmonary oscillations
,” Am. Heart J.
107
(3
), 612
–615
(1984
).35.
S. M. Pincus, I. M. Gladstone, and R. A. Ehrenkranz, “A regularity statistic for medical data analysis,” J. Clinical Monitoring (in press).
36.
J. E.
Skinner
, C.
Carpeggiani
, C. E.
Landisman
, and K. W.
Fulton
, “The correlation dimension of heartbeat intervals is reduced in conscious pigs by myocardial ischemia
,” Circ. Res.
68
, 966
–976
(1991
).37.
D. T.
Kaplan
, M. I.
Furman
, S. M.
Pincus
, S.
Ryan
, L.
Lipsitz
, and A. L.
Goldberger
, “Aging and the complexity of cardiovascular dynamics
,” Biophys.
59
, 945
–949
(1991
).38.
L.
Glass
and C. P.
Malta
, “Chaos in multi-looped negative feedback systems
,” J. Theoret. Biol.
145
, 217
–223
(1990
).39.
M. C.
Mackey
and L.
Glass
, “Oscillation and chaos in physiological control systems
,” Science
197
, 287
–289
(1977
);U.
an der Heiden
and M. C.
Mackey
, “The dynamics of production and destruction: analytic insight into complex behavior
,” J. Math. Biol.
8
, 345
–364
(1982
).40.
J. Losson (personal communication).
41.
E.
Ott
, C.
Grebogi
, and J. A.
Yorke
, “Controlling chaos
,” Phys. Rev. Lett.
64
(11
), 1196
–1199
(1990
);W. L.
Ditto
, S. N.
Rauseo
, M. L.
Spano
, “Experimental control of chaos
,” Phys. Rev. Lett.
65
(26
), 3211
–3214
(1990
)., Phys. Rev. Lett.
42.
P.
Bak
, C.
Tang
, and K.
Wiesenfeld
, “Self-organized criticality
,” Phys. Rev. A
38
(1
), 364
–374
(1988
);
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