The capability of 3D printing technologies for direct production of complex 3D structures in a single step has recently attracted an ever increasing interest within the field of microfluidics. Recently, ultrafast lasers have also allowed developing new methods for production of internal microfluidic channels within the bulk of glass and polymer materials by direct internal 3D laser writing. This review critically summarizes the latest advances in the production of microfluidic 3D structures by using 3D printing technologies and direct internal 3D laser writing fabrication methods. Current applications of these rapid prototyped microfluidic platforms in biology will be also discussed. These include imaging of cells and living organisms, electrochemical detection of viruses and neurotransmitters, and studies in drug transport and induced-release of adenosine triphosphate from erythrocytes.
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September 2014
Research Article|
October 16 2014
Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications
P. F. O'Neill;
P. F. O'Neill
1Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering,
Dublin City University
, Dublin, Ireland
2Irish Separation Science Cluster, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
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A. Ben Azouz;
A. Ben Azouz
1Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering,
Dublin City University
, Dublin, Ireland
2Irish Separation Science Cluster, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
3Insight Centre for Data Analytics, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
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M. Vázquez;
M. Vázquez
a)
1Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering,
Dublin City University
, Dublin, Ireland
2Irish Separation Science Cluster, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
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J. Liu;
J. Liu
1Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering,
Dublin City University
, Dublin, Ireland
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S. Marczak;
S. Marczak
4Centre for Microfluidics and Medical Diagnostics,
University of Notre Dame
, Notre Dame, Indiana 46556, USA
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Z. Slouka;
Z. Slouka
4Centre for Microfluidics and Medical Diagnostics,
University of Notre Dame
, Notre Dame, Indiana 46556, USA
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H. C. Chang;
H. C. Chang
4Centre for Microfluidics and Medical Diagnostics,
University of Notre Dame
, Notre Dame, Indiana 46556, USA
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D. Diamond;
D. Diamond
3Insight Centre for Data Analytics, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
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D. Brabazon
D. Brabazon
1Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering,
Dublin City University
, Dublin, Ireland
2Irish Separation Science Cluster, National Centre for Sensor Research,
Dublin City University
, Dublin, Ireland
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a)
Author to whom correspondence should be addressed. Electronic mail: [email protected]. Tel.: +353 1 700 7602.
Biomicrofluidics 8, 052112 (2014)
Article history
Received:
June 30 2014
Accepted:
October 06 2014
Citation
P. F. O'Neill, A. Ben Azouz, M. Vázquez, J. Liu, S. Marczak, Z. Slouka, H. C. Chang, D. Diamond, D. Brabazon; Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications. Biomicrofluidics 1 September 2014; 8 (5): 052112. https://doi.org/10.1063/1.4898632
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