We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
References
1.
S.
Sershen
and J.
West
, Adv. Drug Delivery Rev.
54
, 1225
–1235
(2002
).2.
N.-C.
Tsai
and C.-T.
Sue
, Sens. Actuators, A
134
, 555
–564
(2007
).3.
C. L.
Stevenson
, J. T.
Santini
, Jr., and R.
Langer
, Adv. Drug Delivery Rev.
64
, 1590
–1602
(2012
).4.
T.
Okano
, Y. H.
Bae
, H.
Jacobs
, and S. W.
Kim
, J. Controlled Release
11
, 255
–265
(1990
).5.
I. C.
Kwon
, Y. H.
Bae
, and S. W.
Kim
, Nature
354
, 291
–293
(1991
).6.
T.
Hoare
, J.
Santamaria
, G. F.
Goya
, S.
Irusta
, D.
Lin
, S.
Lau
, R.
Padera
, R.
Langer
, and D. S.
Kohane
, Nano Lett.
9
(10
), 3651
–3657
(2009
).7.
E.
Mathiowitz
and M. D.
Cohen
, J. Membr. Sci.
40
, 1
–26
(1989
).8.
J.
Kost
, K.
Leong
, and R.
Langer
, Proc. Natl. Acad. Sci. USA
86
, 7663
–7666
(1989
).9.
T.-Y.
Liu
, S.-H.
Hu
, D.-M.
Liu
, S.-Y.
Chen
, and I.-W.
Chen
, Nano Today
4
, 52
–65
(2009
).10.
S. J.
Son
, J.
Reichel
, B.
He
, M.
Schuchman
, and S. B.
Lee
, J. Am. Chem. Soc.
127
, 7316
–7317
(2005
).11.
F. N.
Pirmoradi
, J. K.
Jackson
, H. M.
Burt
, and M.
Chiao
, Lab Chip
11
, 2744
–2752
(2011
).12.
A. V.
Lemoff
and A. P.
Lee
, Sens. Actuators, B
63
, 178
–185
(2000
).13.
H.
So
, A. P.
Pisano
, and Y. H.
Seo
, Lab Chip
14
, 2240
–2248
(2014
).14.
15.
V.
Singhal
, S. V.
Garimella
, and J. Y.
Murthy
, Sens. Actuators, A
113
, 226
–235
(2004
).16.
S.
Rosa
and F. T.
Pinho
, Int. J. Heat Fluid Flow
27
, 319
–328
(2006
).17.
Y.-C.
Su
and L.
Lin
, J. Microelectromech. Syst.
13
, 75
–82
(2004
).18.
F. N.
Pirmoradi
, L.
Cheng
, and M.
Chiao
, J. Micromech. Microeng.
20
, 015032
(2010
).© 2014 AIP Publishing LLC.
2014
AIP Publishing LLC
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