Treatment of surfaces to change the interaction of fluids with them is a critical step in constructing useful microfluidics devices, especially those used in biological applications. Silanization, the generic term applied to the formation of organosilane monolayers on substrates, is both widely reported in the literature and troublesome in actual application for the uninitiated. These monolayers can be subsequently modified to produce a surface of a specific functionality. Here various organosilane deposition protocols and some application notes are provided as a basis for the novice reader to construct their own silanization procedures, and as a practical resource to a broader range of techniques even for the experienced user.
REFERENCES
1.
2.
C.
Hahn
, C.
Leitner
, T.
Weinbrenner
, R.
Schlapak
, A.
Tinazli
, R.
Tampé
, B.
Lackner
, C.
Steindl
, P.
Hinterdorfer
, H.
Gruber
, and M.
Holzl
, Bioconjugate Chem.
18
, 247
(2007
).3.
T.
Koyano
, M.
Saito
, Y.
Miyamoto
, K.
Kaifu
, and M.
Kato
, Biotechnol. Prog.
12
, 141
(1996
).4.
J.
Mooney
, A.
Hunt
, J.
McIntosh
, C.
Liberko
, B.
Walba
, and C.
Rogers
, Proc. Natl. Acad. Sci.
93
, 12287
(1996
).5.
G. J.
Zhang
, T.
Tanii
, T.
Zako
, T.
Hosaka
, Y.
Kanari
, T.
Funatsu
, and I.
Ohdomari
, Small
1
, 833
(2005
).6.
S.
Chen
, J.
Zheng
, L.
Li
, and S.
Jiang
, J. Am. Chem. Soc.
127
, 14473
(2005
).7.
T.
Huang
, J.
Sturgis
, R.
Gomez
, T.
Geng
, R.
Bashir
, A.
Bhunia
, P.
Robinson
, and M.
Ladisch
, Biotechnol. Bioeng.
81
, 618
(2003
).8.
C.
Boozer
, Q.
Yu
, S.
Chen
, C.-Y.
Lee
, J.
Homola
, S. S.
Yee
, and S.
Jiang
, Sens. Actuators B
90
, 22
(2003
).9.
T.
Wink
, S.
Zuilen
, A.
Bult
, and W.
Bennekom
, Analyst
122
, 43
(1997
).10.
N.
Chaki
and K.
Vijayamohanan
, Biosens. Bioelectron.
17
, 1
(2002
).11.
H.
Handa
, S.
Gurezynski
, M.
Jackson
, G.
Auner
, J.
Walker
, and G.
Mao
, Surf. Sci.
602
, 1392
(2008
).12.
Z. A.
Gurard-Levin
and M.
Mrksich
, Annu. Rev. Anal. Chem.
1
, 767
(2008
).13.
Y.
Zhang
, H.
Yu
, J.
Qin
, and B.
Lin
, Biomicrofluidics
3
, 044105
(2009
).14.
C.
Lorenz
, J.
Lane
, M.
Chandross
, M.
Stevens
, and G.
Grest
, Langmuir
25
, 4535
(2009
).15.
O.
Ducloux
, E.
Galopin
, F.
Zoueshtiagh
, A.
Merlen
, and V.
Thomy
, Biomicrofluidics
4
, 011102
(2010
).16.
17.
J. C.
Love
, L.
Estroff
, J.
Kriebel
, R.
Nuzzo
, and G.
Whitesides
, Chem. Rev.
1103
(2005
).18.
W.
Senaratne
, L.
Andruzzi
, and C.
Ober
, Biomacromolecules
6
, 2427
(2005
).19.
J.
Love
, L.
Estroff
, J.
Kriebel
, R.
Nuzzo
, and G.
Whitesides
, Chem. Rev.
105
, 1103
(2005
).20.
M.
Sung
and Y.
Kim
, Bull. Korean Chem. Soc.
22
, 748
(2001
).21.
G.
Toworfe
, R.
Composto
, I.
Shapiro
, and P.
Ducheyne
, Biomaterials
27
, 631
(2006
).22.
M.
Lim
, K.
Feng
, X.
Chen
, N.
Wu
, A.
Raman
, J.
Nightingale
, E.
Gawalt
, D.
Korakakis
, L.
Hornak
, and A.
Timperman
, Langmuir
23
, 2444
(2007
).23.
J.
Gooding
, F.
Mearns
, W.
Yang
, and J.
Liu
, Electroanalysis
15
, 81
–96
(2003
).24.
25.
C.
Corso
, A.
Dickherber
, and W.
Hunt
, Biosens. Bioelectron.
24
, 805
(2008
).26.
H.
Sugimura
, A.
Hozumi
, T.
Kameyama
, and O.
Takai
, Surf. Interface Anal.
34
, 550
(2002
).27.
H.
Sugimura
and N.
Nakagiri
, J. Photopolym. Sci. Technol.
10
, 661
(1997
).28.
G. A.
Carson
and S.
Granick
, J. Mater. Res. Soc.
5
, 1746
(1990
).29.
L. M.
Fischer
, “Development of silicon carbonitride nanomechanical resonators for biological detection applications
”, M.Sc. Thesis, University of Alberta
(Canada), 2007
.30.
J.
Quinton
, L.
Thomsen
, and P.
Dastoor
, Surf. Interface Anal.
25
, 931
(1997
).31.
K.
Choi
, T.-J.
Eom
, and C.
Lee
, Thin Solid Films
435
, 227
(2003
).32.
See supplementary material at http://dx.doi.org/10.1063/1.3625605 for complete multimedia demonstration of organic silanisation of a surface.
33.
34.
S.
Nihonyanagi
, A.
Eftekhari-Bafrooei
, J.
Hines
, and E.
Borguet
, Langmuir
24
, 5161
(2008
).35.
G.
Campbell
and R.
Mutharasan
, Biosens. Bioelectron.
21
, 462
(2005
).36.
S.
Krishnamoorthy
, T.
Bei
, E.
Zoumakis
, G.
Chrousos
, and A.
Iliadis
, Biosens. Bioelectron.
22
, 707
(2006
).37.
S. V.
Rao
, K. W.
Anderson
, and L. G.
Bachas
, Microchim. Acta
128
, 127
(1998
).38.
F.
Rusmini
, Z.
Zhong
, and J.
Feijen
, Biomacromolecules
8
, 1775
(2007
).39.
B.
Pattier
, J.-F.
Bardeau
, A. G.
Mathieu Edely
, and N.
Delorme
, Langmuir
24
, 821
(2008
).40.
C.
Priest
, Biomicrofluidics
4
, 032206
(2010
).41.
J.
Bennès
, S.
Ballandras
, and F.
Chérioux
, Appl. Surf. Sci.
255
, 1796
(2008
).42.
N. L.
Jeon
, K.
Finnie
, K.
Branshaw
, and R.
Nuzzo
, Langmuir
13
, 3382
(1997
).43.
Y.
Schmitt
, H.
Hähl
, C.
Gilow
, H.
Mantz
, K.
Jacobs
, O.
Leidinger
, M.
Bellion
, and L.
Santen
, Biomicrofluidics
4
, 032201
(2010
).44.
F.
Guan
, M.
Chen
, W.
Yang
, J.
Wang
, R.
Zhang
, S.
Yang
, and O.
Xue
, Appl. Surf. Sci.
230
, 131
(2004
).45.
J.
Friend
and L.
Yeo
, Biomicrofluidics
4
, 026502
(2010
).46.
M.
Zhang
, J.
Wu
, L.
Wang
, K.
Xiao
, and W.
Wen
, Lab Chip
10
, 1199
(2010
).47.
D.
Morecroft
, J. K. W.
Yang
, S.
Schuster
, K. K.
Berggren
, Q.
Xia
, W.
Wu
, and R. S.
Williams
, J. Vac. Sci. Technol. B
27
, 2837
(2009
).48.
H.
Mizuno
and J.
Buriak
, Appl. Mater. Interfaces
1
, 2711
(2009
).49.
H.
Schmolke
, S.
Demming
, A.
Edlich
, V.
Magdanz
, S.
Büttgenbach
, E.
Franco-Lara
, R.
Krull
, and C.-P.
Klages
, Biomicrofluidics
4
, 044113
(2010
).50.
U.
Jönsson
, G.
Olofsson
, M.
Malmqvist
, and I.
Rönnberg
, Thin Solid Films
124
, 117
(1985
).51.
I. Yield Engineering Systems (YES), Vapor Deposition Systems—YES-1224 and YES-1224P, Manufacturer Data Sheet (
2011
).52.
T. G.
Waddell
, D. E.
Leyden
, and M. T.
DeBello
, J. Am. Chem. Soc.
103
, 5303
(1981
).53.
M.
Mrksich
and G.
Whitesides
, Trends Biotechnol
13
, 228
(1995
).54.
C.
Ercole
, M. D.
Gallo
, L.
Mosiello
, S.
Baccella
, and A.
Lepidi
, Sens. Actuators B
91
, 163
(2003
).55.
Z.
Zhang
, C.
Crozatier
, M. L.
Berre
, and Y.
Chen
, Microelectron. Eng.
78-79
, 556
(2005
).56.
W.
Laiwattanapaisal
, J.
Yakovleva
, M.
Bengtsson
, T.
Laurell
, S.
Wiyakrutta
, V.
Meevootisom
, O.
Chailapakul
, and J.
Emnéus
, Biomicrofluidics
3
, 014104
(2009
).57.
L.
Yu
, C. M.
Li
, Y.
Liu
, J.
Gao
, W.
Wang
, and Y.
Gan
, Lab on a Chip
9
, 1243
(2009
).58.
M.
Hu
, S.
Noda
, T.
Okubo
, Y.
Yamaguchi
and H.
Komiyama
, Appl. Surf. Sci.
181
, 307
(2001
).59.
S.
Follstaedt
, J.
Last
, D.
Cheung
, P.
Gourley
, and D.
Saski
, Sandia Report, 2000
.60.
K.
Bierbaum
, M.
Kinzler
, C.
Woll
, M.
Grunze
, G.
Hahner
, S.
Heid
, and F.
Effenberger
, Langmuir
11
, 512
(1995
).61.
S.
Kulkarni
, S.
Mirji
, A.
Mandale
, R.
Gupta
, and K.
Vijayamohanan
, Mater. Lett.
3890
(2005
).62.
M.
Wang
, K.
Liechti
, Q.
Wang
, and J.
White
, Langmuir
21
, 1848
(2005
).63.
N. G.
Semaltianos
, J.
Pastol
, and P.
Doppelt
, Appl. Surf. Sci.
222
, 102
(2004
).64.
A.
Mahapatro
, A.
Scott
, A.
Manning
, and D.
Janes
, Appl. Phys. Lett.
88
, 151917
(2006
).© 2011 American Institute of Physics.
2011
American Institute of Physics
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