Monitoring platelet aggregation is crucial for predicting thrombotic diseases and identifying the risk of bleeding or resistance to antiplatelet drugs. This study developed a microfluidic device to measure platelet activation with high sensitivity. By controlling exposure time through repeated reinjections, the device enables the detection of subtle changes in platelet activity influenced by lifestyle factors, such as alcohol consumption. Using computational fluid dynamics simulations, the design was optimized to achieve moderate shear stresses and fabricated with 3D printing. Experimental results revealed that pillars biased to one side partially accelerate the flow and inhibit platelet adhesion. A distinct difference in platelet adhesion was clearly observed before and after alcohol consumption. Despite the high standard deviations in platelet adhesion area, hematocrit, and viscosity after alcohol consumption, the area covered by adhered platelets increased by 3.12 times compared to that before alcohol consumption. This microfluidic chip offers potential for personalized health monitoring by distinguishing platelet variations caused by lifestyle or dietary habits. However, challenges such as reinjection procedures and large sample volumes require further investigation.
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January 2025
Research Article|
January 03 2025
Design of 3D printed chip to improve sensitivity of platelet adhesion through reinjection: Effect of alcohol consumption on platelet adhesion
Haebeen Kim
;
Haebeen Kim
a)
(Validation, Writing – original draft, Writing – review & editing)
1
School of Mechanical Engineering, Pusan National University
, Busan, South Korea
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Hae-Ryoun Park
;
Hae-Ryoun Park
b)
(Funding acquisition, Supervision)
2
Department of Oral Pathology, School of Dentistry, Pusan National University
, Yangsan, South Korea
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Jae Min Song
;
Jae Min Song
c)
(Validation, Writing – review & editing)
3
Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University
, Yangsan, South Korea
4
Dental and Life Science Institute, School of Dentistry, Pusan National University
, Yangsan, South Korea
c)Authors to whom correspondence should be addressed: [email protected], Tel.: +82-51-240-7432 and [email protected], Tel.: +82-51-510-2474, Fax: +82-51-512-5236.
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Eunseop Yeom
Eunseop Yeom
c)
(Funding acquisition, Supervision, Validation, Writing – review & editing)
1
School of Mechanical Engineering, Pusan National University
, Busan, South Korea
c)Authors to whom correspondence should be addressed: [email protected], Tel.: +82-51-240-7432 and [email protected], Tel.: +82-51-510-2474, Fax: +82-51-512-5236.
Search for other works by this author on:
c)Authors to whom correspondence should be addressed: [email protected], Tel.: +82-51-240-7432 and [email protected], Tel.: +82-51-510-2474, Fax: +82-51-512-5236.
a)
Electronic mail: [email protected]
b)
Electronic mail: [email protected]
Biomicrofluidics 19, 014101 (2025)
Article history
Received:
September 05 2024
Accepted:
December 19 2024
Citation
Haebeen Kim, Hae-Ryoun Park, Jae Min Song, Eunseop Yeom; Design of 3D printed chip to improve sensitivity of platelet adhesion through reinjection: Effect of alcohol consumption on platelet adhesion. Biomicrofluidics 1 January 2025; 19 (1): 014101. https://doi.org/10.1063/5.0237452
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