In the field of microfluidics, high-pressure microfluidics technology, which utilizes high driving pressure for microfluidic analysis, is an evolving technology. This technology combines microfluidics and pressurization, where the flow of fluid is controlled by means of high-pressure-driven devices greater than 10 MPa. This paper first reviews the existing high-pressure microfluidics systems and describes their components and applications. Then, it summarizes several materials used in the microfabrication of high-pressure microfluidics chips, reviewing their properties, processing methods, and bonding methods. In addition, advanced laser processing techniques for the microfabrication of high-pressure microfluidics chips are described. Last, the paper examines the analytical detection methods employed in high-pressure microfluidics systems, encompassing optical and electrochemical detection methods. The review of analytical detection methods shows the different functions and application scenarios of high-pressure microfluidics systems. In summary, this study provides an efficient and advanced microfluidics system, which can be widely used in chemical engineering, food industry, and environmental engineering under high pressure conditions.
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January 2025
Review Article|
January 06 2025
Processing and inspection of high-pressure microfluidics systems: A review
Jiangyi Song
;
Jiangyi Song
(Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation)
1
School Energy and Mechanical Engineering, Shanghai University of Electric Power
, Shanghai 200090, China
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Shaoxin Meng
;
Shaoxin Meng
(Project administration, Resources, Software)
2
State Key Laboratory of Power Grid Environmental Protection
, Wuhan, Hubei 430074, China
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Jianben Liu
;
Jianben Liu
(Conceptualization, Software, Writing – original draft)
2
State Key Laboratory of Power Grid Environmental Protection
, Wuhan, Hubei 430074, China
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Naichao Chen
Naichao Chen
a)
(Methodology, Project administration, Supervision)
1
School Energy and Mechanical Engineering, Shanghai University of Electric Power
, Shanghai 200090, China
3
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power
, Shanghai 200090, China
4
Shanghai Non-Carbon Energy Conversion and Utilization Institute
, Shanghai 200240, China
a)Author to whom correspondence should be addressed: [email protected]. Tel.: +6-21-61655270. Fax: +
86-21-61655270
.
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a)Author to whom correspondence should be addressed: [email protected]. Tel.: +6-21-61655270. Fax: +
86-21-61655270
.
Biomicrofluidics 19, 011501 (2025)
Article history
Received:
August 26 2024
Accepted:
December 18 2024
Citation
Jiangyi Song, Shaoxin Meng, Jianben Liu, Naichao Chen; Processing and inspection of high-pressure microfluidics systems: A review. Biomicrofluidics 1 January 2025; 19 (1): 011501. https://doi.org/10.1063/5.0235201
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