The vascular network plays an essential role in the maintenance of all organs in the body via the regulated delivery of oxygen and nutrients, as well as tissue communication via the transfer of various biological signaling molecules. It also serves as a route for drug administration and affects pharmacokinetics. Due to this importance, engineers have sought to create physiologically relevant and reproducible vascular systems in tissue, considering cell–cell and extracellular matrix interaction with structural and physical conditions in the microenvironment. Extracellular vesicles (EVs) have recently emerged as important carriers for transferring proteins and genetic material between cells and organs, as well as for drug delivery. Vascularized platforms can be an ideal system for studying interactions between blood vessels and EVs, which are crucial for understanding EV-mediated substance transfer in various biological situations. This review summarizes recent advances in vascularized platforms, standard and microfluidic-based techniques for EV isolation and characterization, and studies of EVs in vascularized platforms. It provides insights into EV-related (patho)physiological regulations and facilitates the development of EV-based therapeutics.
Skip Nav Destination
Article navigation
September 2024
Review Article|
September 23 2024
Vascularized platforms for investigating cell communication via extracellular vesicles
Junyoung Kim
;
Junyoung Kim
(Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
Search for other works by this author on:
Jooyoung Ro
;
Jooyoung Ro
(Conceptualization, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
Search for other works by this author on:
Yoon-Kyoung Cho
Yoon-Kyoung Cho
a)
(Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
a)Author to whom correspondence should be addressed: ykcho@unist.ac.kr
Search for other works by this author on:
a)Author to whom correspondence should be addressed: ykcho@unist.ac.kr
Biomicrofluidics 18, 051504 (2024)
Article history
Received:
May 28 2024
Accepted:
September 03 2024
Citation
Junyoung Kim, Jooyoung Ro, Yoon-Kyoung Cho; Vascularized platforms for investigating cell communication via extracellular vesicles. Biomicrofluidics 1 September 2024; 18 (5): 051504. https://doi.org/10.1063/5.0220840
Download citation file:
Sign in
Don't already have an account? Register
Sign In
You could not be signed in. Please check your credentials and make sure you have an active account and try again.
Pay-Per-View Access
$40.00
79
Views
Citing articles via
Recent developments in preventing catheter-related infections based on biofilms: A comprehensive review
Byeongchan So, Jongwon Kim, et al.
Trajectory analysis of Bacillus subtilis in micro-droplets
Yangyang Tang, Xiaolei Cao, et al.
Related Content
Extracellular Matrix Proteins, Alkaline Phosphatase and Pyrophosphate as Molecular Determinants of Bone, Tooth, Kidney and Vascular Calcification
AIP Conference Proceedings (September 2008)
Nanostructure enabled extracellular vesicles separation and detection
Nanotechnol. Precis. Eng. (September 2023)
A microfluidic membrane device to mimic critical components of the vascular microenvironment
Biomicrofluidics (March 2011)
Isolation of cancer-derived extracellular vesicle subpopulations by a size-selective microfluidic platform
Biomicrofluidics (June 2020)
Applications of extracellular vesicles in tissue regeneration
Biomicrofluidics (January 2020)