The vascular network plays an essential role in the maintenance of all organs in the body via the regulated delivery of oxygen and nutrients, as well as tissue communication via the transfer of various biological signaling molecules. It also serves as a route for drug administration and affects pharmacokinetics. Due to this importance, engineers have sought to create physiologically relevant and reproducible vascular systems in tissue, considering cell–cell and extracellular matrix interaction with structural and physical conditions in the microenvironment. Extracellular vesicles (EVs) have recently emerged as important carriers for transferring proteins and genetic material between cells and organs, as well as for drug delivery. Vascularized platforms can be an ideal system for studying interactions between blood vessels and EVs, which are crucial for understanding EV-mediated substance transfer in various biological situations. This review summarizes recent advances in vascularized platforms, standard and microfluidic-based techniques for EV isolation and characterization, and studies of EVs in vascularized platforms. It provides insights into EV-related (patho)physiological regulations and facilitates the development of EV-based therapeutics.
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September 2024
Review Article|
September 23 2024
Vascularized platforms for investigating cell communication via extracellular vesicles
Junyoung Kim
;
Junyoung Kim
(Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
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Jooyoung Ro
;
Jooyoung Ro
(Conceptualization, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
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Yoon-Kyoung Cho
Yoon-Kyoung Cho
a)
(Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing)
1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST)
, Ulsan 44919, Republic of Korea
2
Center for Algorithmic and Robotized Synthesis, Institute for Basic Science (IBS)
, Ulsan 44919, Republic of Korea
a)Author to whom correspondence should be addressed: ykcho@unist.ac.kr
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a)Author to whom correspondence should be addressed: ykcho@unist.ac.kr
Biomicrofluidics 18, 051504 (2024)
Article history
Received:
May 28 2024
Accepted:
September 03 2024
Citation
Junyoung Kim, Jooyoung Ro, Yoon-Kyoung Cho; Vascularized platforms for investigating cell communication via extracellular vesicles. Biomicrofluidics 1 September 2024; 18 (5): 051504. https://doi.org/10.1063/5.0220840
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