High-quality-factor (Q) optical microcavities have attracted extensive interest due to their unique ability to confine light for resonant circulation at the micrometer scale. Particular attention has been paid to optical whispering-gallery mode (WGM) microcavities to harness their strong light–matter interactions for biological applications. Remarkably, the combination of high-Q optical WGM microcavities with microfluidic technologies can achieve a synergistic effect in the development of high-sensitivity optofluidic sensors for many emerging biological analysis applications, such as the detection of proteins, nucleic acids, viruses, and exosomes. They can also be utilized to investigate the behavior of living cells in human organisms, which may provide new technical solutions for studies in cell biology and biophysics. In this paper, we briefly review recent progress in high-Q microcavity-based optofluidic sensor technologies and their applications in biological analysis.
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July 2024
Review Article|
August 27 2024
High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis
Zhizheng Wang
;
Zhizheng Wang
(Investigation, Writing – original draft)
Department of Electrical and Electronic Engineering, Photonics Research Institute, The Hong Kong Polytechnic University
, Kowloon, Hong Kong SAR, China
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Bin Zhou;
Bin Zhou
(Investigation, Writing – original draft)
Department of Electrical and Electronic Engineering, Photonics Research Institute, The Hong Kong Polytechnic University
, Kowloon, Hong Kong SAR, China
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A. Ping Zhang
A. Ping Zhang
a)
(Conceptualization, Funding acquisition, Supervision, Writing – review & editing)
Department of Electrical and Electronic Engineering, Photonics Research Institute, The Hong Kong Polytechnic University
, Kowloon, Hong Kong SAR, China
a)Author to whom correspondence should be addressed: azhang@polyu.edu.hk
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a)Author to whom correspondence should be addressed: azhang@polyu.edu.hk
Biomicrofluidics 18, 041502 (2024)
Article history
Received:
January 25 2024
Accepted:
August 12 2024
Citation
Zhizheng Wang, Bin Zhou, A. Ping Zhang; High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis. Biomicrofluidics 1 July 2024; 18 (4): 041502. https://doi.org/10.1063/5.0200166
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