Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.
Skip Nav Destination
Article navigation
January 2021
Review Article|
February 04 2021
Increasing the packing density of assays in paper-based microfluidic devices
Sajjad Rahmani Dabbagh
;
Sajjad Rahmani Dabbagh
1
Department of Mechanical Engineering, Koç University
, Sariyer, Istanbul 34450, Turkey
2
Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University
, Sariyer, Istanbul 34450, Turkey
Search for other works by this author on:
Elaina Becher;
Elaina Becher
3
Department of Biomedical Engineering, University of Connecticut
, Storrs, Connecticut 06269, USA
Search for other works by this author on:
Fariba Ghaderinezhad;
Fariba Ghaderinezhad
4
Department of Mechanical Engineering, University of Connecticut
, Storrs, Connecticut 06269, USA
Search for other works by this author on:
Hayati Havlucu;
Hayati Havlucu
2
Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University
, Sariyer, Istanbul 34450, Turkey
Search for other works by this author on:
Oguzhan Ozcan;
Oguzhan Ozcan
2
Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University
, Sariyer, Istanbul 34450, Turkey
Search for other works by this author on:
Mehmed Ozkan;
Mehmed Ozkan
5
Boğaziçi Institute of Biomedical Engineering, Boğaziçi University
, Çengelköy, Istanbul 34684, Turkey
Search for other works by this author on:
Ali Kemal Yetisen;
Ali Kemal Yetisen
6
Department of Chemical Engineering, Imperial College London
, London SW7 2AZ, United Kingdom
Search for other works by this author on:
Savas Tasoglu
Savas Tasoglu
a)
1
Department of Mechanical Engineering, Koç University
, Sariyer, Istanbul 34450, Turkey
2
Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University
, Sariyer, Istanbul 34450, Turkey
5
Boğaziçi Institute of Biomedical Engineering, Boğaziçi University
, Çengelköy, Istanbul 34684, Turkey
7
Koc University Research Center for Translational Medicine
, Koc University, Sariyer, Istanbul 34450, Turkey
8
Center for Life Sciences and Technologies, Bogazici University
, Bebek, Istanbul 34470, Turkey
a)Author to whom correspondence should be addressed: stasoglu@ku.edu.tr
Search for other works by this author on:
a)Author to whom correspondence should be addressed: stasoglu@ku.edu.tr
Biomicrofluidics 15, 011502 (2021)
Article history
Received:
January 05 2021
Accepted:
January 07 2021
Citation
Sajjad Rahmani Dabbagh, Elaina Becher, Fariba Ghaderinezhad, Hayati Havlucu, Oguzhan Ozcan, Mehmed Ozkan, Ali Kemal Yetisen, Savas Tasoglu; Increasing the packing density of assays in paper-based microfluidic devices. Biomicrofluidics 1 January 2021; 15 (1): 011502. https://doi.org/10.1063/5.0042816
Download citation file:
Sign in
Don't already have an account? Register
Sign In
You could not be signed in. Please check your credentials and make sure you have an active account and try again.
Pay-Per-View Access
$40.00
Citing articles via
NanoRidge filters: Fabrication strategies and performance optimization for nano-scale microfluidic particle filtration
Jared P. Smithers, Jerry Sheu, et al.
A flexible strategy to fabricate trumpet-shaped porous PDMS membranes for organ-on-chip application
Yingying Xie, Yaqiong Guo, et al.
Recent advances in portable devices for environmental monitoring applications
Thi Ngoc Diep Trinh, Nguyen Khoi Song Tran, et al.