Slip-driven microfluidic devices can manipulate fluid by the relative movement of microfluidic plates that are in close contact. Since the demonstration of the first SlipChip device, many slip-driven microfluidic devices with different form factors have been developed, including SlipPAD, SlipDisc, sliding stripe, and volumetric bar chart chip. Slip-driven microfluidic devices can be fabricated from glass, quartz, polydimethylsiloxane, paper, and plastic with various fabrication methods: etching, casting, wax printing, laser cutting, micromilling, injection molding, etc. The slipping operation of the devices can be performed manually, by a micrometer with a base station, or autonomously, by a clockwork mechanism. A variety of readout methods other than fluorescence microscopy have been demonstrated, including both fluorescence detection and colorimetric detection by mobile phones, direct visual detection, and real-time fluorescence imaging. This review will focus on slip-driven microfluidic devices for nucleic acid analysis, including multiplex nucleic acid detection, digital nucleic acid quantification, real-time nucleic acid amplification, and sample-in-answer-out nucleic acid analysis. Slip-driven microfluidic devices present promising approaches for both life science research and clinical molecular diagnostics.
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July 2019
Review Article|
July 12 2019
Slip-driven microfluidic devices for nucleic acid analysis
Weiyuan Lyu;
Weiyuan Lyu
1
School of Biomedical Engineering, Shanghai Jiao Tong University
, 1954 Huashan Road, Shanghai 200030, China
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Mengchao Yu;
Mengchao Yu
1
School of Biomedical Engineering, Shanghai Jiao Tong University
, 1954 Huashan Road, Shanghai 200030, China
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Haijun Qu;
Haijun Qu
1
School of Biomedical Engineering, Shanghai Jiao Tong University
, 1954 Huashan Road, Shanghai 200030, China
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Ziqing Yu;
Ziqing Yu
1
School of Biomedical Engineering, Shanghai Jiao Tong University
, 1954 Huashan Road, Shanghai 200030, China
2
Department of Laboratory Medicine, Xiangya School of Medicine, Central South University
, Changsha 410083, China
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Wenbin Du;
Wenbin Du
3
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences
, Beijing 100080, China
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Feng Shen
Feng Shen
a)
1
School of Biomedical Engineering, Shanghai Jiao Tong University
, 1954 Huashan Road, Shanghai 200030, China
a)Author to whom correspondence should be addressed: [email protected]
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a)Author to whom correspondence should be addressed: [email protected]
Biomicrofluidics 13, 041502 (2019)
Article history
Received:
May 07 2019
Accepted:
July 01 2019
Citation
Weiyuan Lyu, Mengchao Yu, Haijun Qu, Ziqing Yu, Wenbin Du, Feng Shen; Slip-driven microfluidic devices for nucleic acid analysis. Biomicrofluidics 1 July 2019; 13 (4): 041502. https://doi.org/10.1063/1.5109270
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