Drug cocktails have been popular for a variety of therapies of complicated diseases. Nevertheless, it is a tediously challenging task to optimize formulations, especially using traditional methods. Hence, an automatic system capable of precise dispensing multiple drugs is of great need. Herein, a new integrated microfluidic system combined with a two-axis traverse module was developed to dispense and mix a small amount of drug combination precisely and automatically. This on-chip dispensing process could be performed with a precise and accurate manner when compared to the manual operations. The efficacy of both single and multiple drugs could be examined through the developed microfluidic system with extremely low variation of drug formulations. Analysis of cell viabilities for normal and tumor cells was also performed to verify potential drug combinations. It is envisioned that this automatic system, which is flexible to combine with standard cell analysis methods and novel drug formulation algorithm, could provide precise and high-throughput drug cocktail formulations and expedite the drug screening processes.
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Research Article|
May 15 2017
Automatic optimization of drug cocktails on an integrated microfluidic system
Wen-Yen Huang;
Wen-Yen Huang
1Department of Power Mechanical Engineering,
National Tsing Hua University
, Hsinchu 30013, Taiwan
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Ching-An Liu
;
Ching-An Liu
2Graduate Institute of Nanomedicine and Medical Engineering,
Taipei Medical School
, Taipei 11031, Taiwan
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Rong-Syuan Fan;
Rong-Syuan Fan
1Department of Power Mechanical Engineering,
National Tsing Hua University
, Hsinchu 30013, Taiwan
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Zhi-Da Lin;
Zhi-Da Lin
1Department of Power Mechanical Engineering,
National Tsing Hua University
, Hsinchu 30013, Taiwan
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Kuan Wang;
Kuan Wang
a)
2Graduate Institute of Nanomedicine and Medical Engineering,
Taipei Medical School
, Taipei 11031, Taiwan
3College of Biomedical Engineering,
Taipei Medical School
, Taipei 11031, Taiwan
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Gwo-Bin Lee
Gwo-Bin Lee
a)
1Department of Power Mechanical Engineering,
National Tsing Hua University
, Hsinchu 30013, Taiwan
4Institute of Biomedical Engineering,
National Tsing Hua University
, Hsinchu 30013, Taiwan
5Institute of NanoEngineering and Microsystems,
National Tsing Hua University
, Hsinchu 30013, Taiwan
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a)
Authors to whom correspondence should be addressed. Electronic addresses: wangk007@gmail.com, Tel.: +886-2-2736-1661, Ext. 7656 and gwobin@pme.nthu.edu.tw, Fax: +886-3-5742495, Tel.: +886-3-5715131 Ext. 33765.
Note: The preliminary results in this paper have been presented at the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2016 Conference, Dublin, Ireland, October 9–13, 2016.
Biomicrofluidics 11, 034109 (2017)
Article history
Received:
February 16 2017
Accepted:
May 03 2017
Citation
Wen-Yen Huang, Ching-An Liu, Rong-Syuan Fan, Zhi-Da Lin, Kuan Wang, Gwo-Bin Lee; Automatic optimization of drug cocktails on an integrated microfluidic system. Biomicrofluidics 1 May 2017; 11 (3): 034109. https://doi.org/10.1063/1.4983614
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