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| January 23 2024
Machine learning classification of cellular states based on the impedance features derived from microfluidic single-cell impedance flow cytometry
Jian Wei, Wenbing Gao et al.
Mitosis is a crucial biological process where a parental cell undergoes precisely controlled functional phases and divides into two daughter cells. Some drugs can inhibit cell mitosis, for instance, ...
| January 12 2024
Microfluidics-based patient-derived disease detection tool for deep learning-assisted precision medicine
Haojun Hua, Yunlan Zhou et al.
Cancer spatial and temporal heterogeneity fuels resistance to therapies. To realize the routine assessment of cancer prognosis and treatment, we demonstrate the development of an Intelligent Disease ...
| October 11 2023
Development of a dual-flow tissue perfusion device for modeling the gastrointestinal tract–brain axis
Lydia Baldwin, Emily J. Jones et al.
Despite the large number of microfluidic devices that have been described over the past decade for the study of tissues and organs, few have become widely adopted. There are many reasons for this ...
| October 27 2022
Yiming Qiao, Zixue Ma et al.
We have determined the susceptibility of T4 DNA (166 kilobase pairs, kbp) to fragmentation under steady shear in a cone-and-plate rheometer. After shearing for at least 30 min at a shear rate of ...
| October 26 2021
High-throughput deterministic pairing and coculturing of single cells in a microwell array using combined hydrodynamic and recirculation flow captures
Lei Fan, Zhangyan Guan et al.
Single-cell level coculture facilitates the study of cellular interactions for uncovering unknown physiological mechanisms, which are crucial for the development of new therapies for diseases. ...
| March 30 2021
Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors
Hanjin Seo, Hyomin Lee
Recent advances in droplet microfluidics have led to the fabrication of versatile vesicles with a structure that mimics the cellular membrane. These artificial cell-like vesicles including ...
| March 01 2024
Marta K. Orlowska, James R. Krycer et al.
The heart is a metabolic “omnivore” and adjusts its energy source depending on the circulating metabolites. Human cardiac organoids, a three-dimensional in vitro model of the heart wall, are a useful ...
| February 29 2024
Photo-addressable microwell devices for rapid functional screening and isolation of pathogen inhibitors from bacterial strain libraries
Niloy Barua, Ashlee M. Herken et al.
Discovery of new strains of bacteria that inhibit pathogen growth can facilitate improvements in biocontrol and probiotic strategies. Traditional, plate-based co-culture approaches that probe ...
| February 29 2024
C. L. Harshbarger
Cancer directly affects one in every three people, and mortality rates strongly correlate with the stage at which diagnosis occurs. Each of the multitude of methods used in cancer diagnostics has its ...