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| October 11 2023
Development of a dual-flow tissue perfusion device for modeling the gastrointestinal tract–brain axis
Lydia Baldwin, Emily J. Jones et al.
Despite the large number of microfluidic devices that have been described over the past decade for the study of tissues and organs, few have become widely adopted. There are many reasons for this ...
| April 27 2023
Microbial stir bars: Light-activated rotation of tethered bacterial cells to enhance mixing in stagnant fluids
Jyoti P. Gurung, Moein Navvab Kashani et al.
Microfluidics devices are gaining significant interest in biomedical applications. However, in a micron-scale device, reaction speed is often limited by the slow rate of diffusion of the reagents. ...
| January 03 2023
3D collagen microchamber arrays for combined chemotherapy effect evaluation on cancer cell numbers and migration
Jingru Yao, Guoqiang Li et al.
Breast cancer metastasis involves complex mechanisms, particularly when patients are undergoing chemotherapy. In tissues, tumor cells encounter cell–cell interactions, cell–microenvironment ...
| October 27 2022
Yiming Qiao, Zixue Ma et al.
We have determined the susceptibility of T4 DNA (166 kilobase pairs, kbp) to fragmentation under steady shear in a cone-and-plate rheometer. After shearing for at least 30 min at a shear rate of ...
| October 26 2021
High-throughput deterministic pairing and coculturing of single cells in a microwell array using combined hydrodynamic and recirculation flow captures
Lei Fan, Zhangyan Guan et al.
Single-cell level coculture facilitates the study of cellular interactions for uncovering unknown physiological mechanisms, which are crucial for the development of new therapies for diseases. ...
| March 30 2021
Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors
Hanjin Seo, Hyomin Lee
Recent advances in droplet microfluidics have led to the fabrication of versatile vesicles with a structure that mimics the cellular membrane. These artificial cell-like vesicles including ...
| December 07 2023
Jun Ando, Rikiya Watanabe
Digital bioanalysis places great emphasis on the highly sensitive and rapid detection of biomolecules at the single-molecule level. Rooted in single-molecule biophysics, this innovative approach ...
| December 06 2023
Effect of the shear rate and residence time on the lysis of AC16 human cardiomyocyte cells via surface acoustic waves
G. Almanza, R. M. Trujillo et al.
The efficient breakage of one cell or a concentration of cells for releasing intracellular material such as DNA, without damaging it, is the first step for several diagnostics or treatment processes. ...
| December 06 2023
Anagha Rama Varma, Parinaz Fathi
Organ-on-a-chip devices are powerful modeling systems that allow researchers to recapitulate the in vivo structures of organs as well as the physiological conditions those tissues are subject to. ...