Three dimensional (3D) printing is a revolutionizing technology, which endows engineers, designers, and manufacturers with the ability to rapidly translate digital sketches into physical objects. The advantages that lie in the high resolution and accuracy of this technique were not concealed from the eyes of tissue engineers that soon harnessed this power for fabrication of complex biological structures. Nevertheless, while the conventional 3D printing scheme is oriented to yield durable and sturdy structures, the delicate nature of the substances used in 3D bioprinting results in fragile and mechanically unstable constructs. This poses a significant restriction that needs to be overcome in order to successfully complete the printing of intact, accurate, and biologically relevant constructs with desirable properties. To address these complications, advanced means of stabilization which are applied during and/or following the printing procedure are constantly being developed. In this review, the rational and principles behind widely used stabilization strategies in extrusion-based bioprinting will be covered. Examples of implementation of these strategies in recently published research in the field of tissue engineering will also be presented and discussed.
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Stabilization strategies in extrusion-based 3D bioprinting for tissue engineering
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December 2018
Review Article|
December 31 2018
Stabilization strategies in extrusion-based 3D bioprinting for tissue engineering
Assaf Shapira;
Assaf Shapira
a)
1
The School for Molecular Cell Biology and Biotechnology, Faculty of Life Sciences, Tel Aviv University
, Tel Aviv 69978, Israel
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Nadav Noor;
Nadav Noor
a)
2
Department of Materials Science and Engineering, Faculty of Engineering, Tel Aviv University
, Tel Aviv 69978, Israel
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Masha Asulin;
Masha Asulin
a)
2
Department of Materials Science and Engineering, Faculty of Engineering, Tel Aviv University
, Tel Aviv 69978, Israel
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Tal Dvir
Tal Dvir
b)
1
The School for Molecular Cell Biology and Biotechnology, Faculty of Life Sciences, Tel Aviv University
, Tel Aviv 69978, Israel
2
Department of Materials Science and Engineering, Faculty of Engineering, Tel Aviv University
, Tel Aviv 69978, Israel
3
The Center for Nanoscience and Nanotechnology, Tel Aviv University
, Tel Aviv 69978, Israel
4
Sagol Center for Regenerative Biotechnology, Tel Aviv University
, Tel Aviv 69978, Israel
b)Author to whom correspondence should be addressed: [email protected]
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a)
A. Shapira, N. Noor, and M. Asulin contributed equally to this work.
b)Author to whom correspondence should be addressed: [email protected]
This paper is part of the Special Topic on 3D Bioprinting: Physical and Chemical Processes.
Appl. Phys. Rev. 5, 041112 (2018)
Article history
Received:
September 09 2018
Accepted:
December 04 2018
Citation
Assaf Shapira, Nadav Noor, Masha Asulin, Tal Dvir; Stabilization strategies in extrusion-based 3D bioprinting for tissue engineering. Appl. Phys. Rev. 1 December 2018; 5 (4): 041112. https://doi.org/10.1063/1.5055659
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