A force field as accurate as quantum mechanics (QMs) and as fast as molecular mechanics (MMs), with which one can simulate a biomolecular system efficiently enough and meaningfully enough to get quantitative insights, is among the most ardent dreams of biophysicists—a dream, nevertheless, not to be fulfilled any time soon. Machine learning force fields (MLFFs) represent a meaningful endeavor in this direction, where differentiable neural functions are parametrized to fit ab initio energies and forces through automatic differentiation. We argue that, as of now, the utility of the MLFF models is no longer bottlenecked by accuracy but primarily by their speed, as well as stability and generalizability—many recent variants, on limited chemical spaces, have long surpassed the chemical accuracy of 1 kcal/mol—the empirical threshold beyond which realistic chemical predictions are possible—though still magnitudes slower than MM. Hoping to kindle exploration and design of faster, albeit perhaps slightly less accurate MLFFs, in this review, we focus our attention on the technical design space (the speed-accuracy trade-off) between MM and ML force fields. After a brief review of the building blocks (from a machine learning-centric point of view) of force fields of either kind, we discuss the desired properties and challenges now faced by the force field development community, survey the efforts to make MM force fields more accurate and ML force fields faster, and envision what the next generation of MLFF might look like.
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