We have investigated the focusing and dynamics of non-spherical polymeric particles in microfluidic flows at finite Reynolds number. The rotational diameter, Dmax, of a particle, regardless of its cross-sectional shape, was found to determine the final focused position, except for the case of asymmetric disks. Additionally, elongated particles with larger Dmax exhibited longer residence times in a horizontal orientation than those with smaller Dmax. These findings inform approaches to hydrodynamically control shaped and barcoded particles for multiplexed biochemical assays.
REFERENCES
1.
L.
Fabris
, M.
Schierhorn
, M.
Moskovits
, and G. C.
Bazan
, Small
6
(14
), 1550
(2010
).2.
J.
Hong
, J. B.
Edel
, and A. J.
deMello
, Drug Discovery Today
14
(3–4
), 134
(2009
).3.
H.
Lee
, J.
Kim
, H.
Kim
, and S.
Kwon
, Nat. Mater.
9
(9
), 745
(2010
).4.
D. C.
Pregibon
, M.
Toner
, and P. S.
Doyle
, Science
315
(5817
), 1393
(2007
).5.
S. C.
Chapin
, D. C.
Appleyard
, D. C.
Pregibon
, and P. S.
Doyle
, Angew. Chem.
123
(10
), 2337
(2011
).6.
7.
S. E.
Chung
, W.
Park
, S.
Shin
, S. A.
Lee
, and S.
Kwon
, Nat. Mater.
7
(7
), 581
(2008
).8.
S. H.
Lee
, S.-E.
Choi
, A. J.
Heinz
, W.
Park
, S.
Han
, Y.
Jung
, and S.
Kwon
, Small
6
(23
), 2668
(2010
).9.
10.
S. C.
Hur
, H. T. K.
Tse
, and D.
Di Carlo
, Lab Chip
10
(3
), 274
(2010
).11.
C. R.
Amenábar
, M.
Di Pasquo
, H.
Carrizo
, and C. L.
Azcuy
, Ameghiniana
43
(2
), 339
(2006
).12.
T.
Chung
and H.
Kim
, Electrophoresis
28
(24
), 4511
(2007
).13.
D.
Dendukuri
, S. S.
Gu
, D. C.
Pregibon
, T. A.
Hatton
, and P. S.
Doyle
, Lab Chip
7
(7
), 818
(2007
).14.
S. C.
Hur
, N. K.
Henderson-MacLennan
, E. R. B.
McCabe
, and D.
Di Carlo
, Lab Chip
11
, 912
(2011
).15.
See supplementary material at http://dx.doi.org/10.1063/1.3608115 for detailed experimental and analytical methods used to understand behavior of non-spherical particles flowing in microchannels based on particle size and shape and fluidic inertia.
16.
17.
K. A.
Bollen
and R. W.
Jackman
, Modern Methods of Data Analysis
(Sage Publication
, Newbery Park, CA
, 1990
), p. 257
.18.
D.
Di Carlo
, J. F.
Edd
, D.
Irimia
, R. G.
Tompkins
, and M.
Toner
, Anal. Chem.
80
(6
), 2204
(2008
).19.
A. J.
Mach
and D.
Di Carlo
, Biotechnol. Bioeng.
107
(2
), 302
(2010
).20.
G. B.
Jeffery
, Proc. R. Soc. London. Ser. A
102
(715
), 161
(1922
).21.
C. G.
Joung
, Rheol. Acta
46
(1
), 143
(2006
).22.
T.
Su
, S.
Seo
, A.
Erlinger
, and A.
Ozcan
, Biotechnol. Bioeng.
102
(3
), 856
(2009
).© 2011 American Institute of Physics.
2011
American Institute of Physics
You do not currently have access to this content.