The flexible cancer sensor based on layer-by-layer self-assembled graphene reported in this letter demonstrates features including ultrahigh sensitivity and low cost due to graphene material properties in nature, self-assembly technique, and polyethylene terephthalate substrate. According to the conductance change of self-assembled graphene, the label free and labeled graphene sensors are capable of detecting very low concentrations of prostate specific antigen down to 4 fg/ml (0.11 fM) and 0.4 pg/ml (11 fM), respectively, which are three orders of magnitude lower than carbon nanotube sensors under the same conditions of design, manufacture, and measurement.

1.
R.
Etzioni
,
N.
Urban
,
S.
Ramsey
,
M.
McIntosh
,
S.
Schwartz
,
B.
Reid
,
J.
Radich
,
G.
Anderson
, and
L.
Hartwell
,
Nat. Rev. Cancer
3
,
243
(
2003
).
2.
H.
Lilja
,
D.
Ulmert
, and
A. J.
Vickers
,
Nat. Rev. Cancer
8
,
268
(
2008
).
3.
Z.
Zhong
,
W.
Wu
,
D.
Wang
,
D.
Wang
,
J.
Shan
,
Y.
Qing
, and
Z.
Zhang
,
Biosens. Bioelectron.
25
,
2379
(
2010
).
4.
J.
Todd
,
B.
Freese
,
A.
Lu
,
D.
Held
,
J.
Morey
,
R.
Livingston
, and
P.
Goix
,
Clin. Chem.
53
,
1990
(
2007
).
5.
L. A.
Tessler
,
J. G.
Reifenberger
, and
R. D.
Mitra
,
Anal. Chem.
81
,
7141
(
2009
).
6.
E.
Stern
,
J. F.
Klemic
,
D. A.
Routenberg
,
P. N.
Wyrembak
,
D. B.
Turner-Evans
,
A. D.
Hamilton
,
D. A.
LaVan
,
T. M.
Fahmy
, and
M. A.
Reed
,
Nature (London)
445
,
519
(
2007
).
7.
M.
Lu
,
D.
Lee
,
W.
Xue
, and
T.
Cui
,
Sens. Actuators, A
150
,
280
(
2009
).
8.
M.
Díaz-González
,
D.
Hernández-Santos
,
M. B.
González-García
, and
A.
Costa-García
,
Talanta
65
,
565
(
2005
).
9.
C.
Campagnolo
,
K. J.
Meyersc
,
T.
Ryand
,
R. C.
Atkinsond
,
Y.
Chene
,
M. J.
Scanlanf
,
G.
Ritterf
,
L. J.
Oldf
, and
C. A.
Bat
,
J. Biochem. Biophys. Methods
61
,
283
(
2004
).
10.
G.
Shekhawat
,
S.
Tark
, and
V. P.
Dravid
,
Science
311
,
1592
(
2006
).
11.
M.
Yue
,
J. C.
Stachowiak
,
H.
Lin
,
R.
Datar
,
R.
Cote
, and
A.
Majumdar
,
Nano Lett.
8
,
520
(
2008
).
12.
J.
Nam
,
C. S.
Thaxton
, and
C. A.
Mirkin
,
Science
301
,
1884
(
2003
).
13.
J.
Zhang
,
L.
Wang
,
D.
Pan
,
S.
Song
,
F.
Boey
,
H.
Zhang
, and
C.
Fan
,
Small
4
,
1196
(
2008
).
14.
J.
Zhang
,
L.
Wang
,
H.
Zhang
,
F.
Boey
,
S.
Song
, and
C.
Fan
,
Small
6
,
201
(
2010
).
15.
J.
Yan
,
S.
Song
,
B.
Li
,
Q.
Zhang
,
Q.
Huang
,
H.
Zhang
, and
C.
Fan
,
Small
6
,
2520
(
2010
).
16.
X.
Yu
,
B.
Munge
,
V.
Patel
,
G.
Jensen
,
A.
Bhirde
,
J. D.
Gong
,
S. N.
Kim
,
J.
Gillespie
,
J. S.
Gutkind
,
F.
Papadimitrakopoulos
, and
J. F.
Rusling
,
J. Am. Chem. Soc.
128
,
11199
(
2006
).
17.
W.
Xue
and
T.
Cui
,
Sens. Actuators B
134
,
981
(
2008
).
18.
G.
Zheng
,
F.
Patolsky
,
Y.
Cui
,
W. U.
Wang
, and
C. M.
Lieber
,
Nat. Biotechnol.
23
,
1294
(
2005
).
19.
J.
Choi
,
B.
Oh
,
Y.
Jang
, and
D.
Kang
,
Appl. Phys. Lett.
93
,
033110
(
2008
).
20.
K. S.
Novoselov
,
A. K.
Geim
,
S. V.
Morozov
,
D.
Jiang
,
Y.
Zhang
,
S. V.
Dubonos
,
I. V.
Grigorieva
, and
A. A.
Firsov
,
Science
306
,
666
(
2004
).
21.
Y.
Ohno
,
K.
Maehashi
,
Y.
Yamashiro
, and
K.
Matsumoto
,
Nano Lett.
9
,
3318
(
2009
).
22.
S.
He
,
B.
Song
,
D.
Li
,
C.
Zhu
,
W.
Qi
,
Y.
Wen
,
L.
Wang
,
S.
Song
,
H.
Fang
, and
C.
Fan
,
Adv. Funct. Mater.
20
,
453
(
2010
).
23.
Q.
He
,
H. G.
Sudibya
,
Z.
Yin
,
S.
Wu
,
H.
Li
,
F.
Boey
,
W.
Huang
,
P.
Chen
, and
H.
Zhang
,
ACS Nano
4
,
3201
(
2010
).
24.
Z.
Wang
,
X.
Zhou
,
J.
Zhang
,
F.
Boey
, and
H.
Zhang
,
J. Phys. Chem. C
113
,
14071
(
2009
).
25.
X.
Zhou
,
Y.
Wei
,
Q.
He
,
F.
Boey
,
Q.
Zhang
, and
H.
Zhang
,
Chem. Commun. (Cambridge)
2010
,
6974
.
26.
J. T.
Robinson
,
F. K.
Perkins
,
E. S.
Snow
,
Z.
Wei
, and
P. E.
Sheehan
,
Nano Lett.
8
,
3137
(
2008
).
27.
K.
Ratinac
,
W.
Yang
,
S.
Ringer
, and
F.
Braet
,
Environ. Sci. Technol.
44
,
1167
(
2010
).
28.
F.
Schedin
,
A. K.
Geim
,
S. V.
Morozov
,
E. W.
Hill
,
P.
Blake
,
M. I.
Katsnelson
, and
K. S.
Novoselov
,
Nature Mater.
6
,
652
(
2007
).
29.
E. H.
Hwang
,
S.
Adam
, and
S.
Das Sarma
,
Phys. Rev. B
76
,
195421
(
2007
).
30.
Y.
Lin
and
P.
Avouris
,
Nano Lett.
8
,
2119
(
2008
).
31.
B. V.
Chikkaveeraiah
,
A.
Bhirde
,
R.
Malhotra
,
V.
Patel
,
J. S.
Gutkind
, and
J. F.
Rusling
,
Anal. Chem.
81
,
9129
(
2009
).
32.
N. V.
Panini
,
G. A.
Messina
,
E.
Salinas
,
H.
Fernandez
, and
J.
Raba
,
Biosens. Bioelectron.
23
,
1145
(
2008
).
33.
J.
Lee
,
Z.
Wang
,
J.
Liu
, and
Y.
Lu
,
J. Am. Chem. Soc.
130
,
14217
(
2008
).
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