The response of resonant-mode cantilever sensors depends on the binding strength of analyte mass to the sensor surface. Comparison of cantilever response to attachment of three macrosized pieces: quartz [300 and , water contact angle ], silanized quartz (, ), and polytetrafluoroethylene (1.5 mg, ), with water and ethanol films indicates that the resonance frequency decrease is larger for higher liquid surface tension and lower contact angle. For example, quartz piece (, ) weighing caused a decrease in the resonance frequency with a water film while the hydrophobic silanized quartz caused a significantly lower frequency shift of .
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