Using the single-scatterer-induced coupling mechanism of a pair of counterpropagating high- whispering-gallery modes (WGMs), we investigate the highly sensitive detection of single nonspherical nanoparticles. The nonspherical particle may produce distinct frequency splitting and additional damping for TE and TM WGMs. This polarization-dependent effect allows for studying the orientation of single biomolecule, molecule-molecule interaction on the microcavity surface, and possibly distinguishing different inner configurations of similar biomolecules.
REFERENCES
1.
F.
Vollmer
, D.
Braun
, A.
Libchaber
, M.
Khoshsima
, I.
Teraoka
, and S.
Arnold
, Appl. Phys. Lett.
80
, 4057
(2002
).2.
E.
Krioukov
, J.
Greve
, and C.
Otto
, Sens. Actuators B
90
, 58
(2003
).3.
W.
Fang
, D. B.
Buchholz
, R. C.
Bailey
, J. F.
Hupp
, R. P. H.
Chang
, and H.
Cao
, Appl. Phys. Lett.
85
, 3666
(2004
).4.
M.
Noto
, M.
Khoshsima
, D.
Keng
, I.
Teraoka
, V.
Kolchenko
, and S.
Arnold
, Appl. Phys. Lett.
87
, 223901
(2005
).5.
I. M.
White
, H.
Oveys
, and X.
Fan
, Opt. Lett.
31
, 1319
(2006
).6.
P.
Zijlstra
, K. L.
van der Molen
, and A. P.
Mosk
, Appl. Phys. Lett.
90
, 161101
(2007
).7.
A.
Francois
and M.
Himmelhaus
, Appl. Phys. Lett.
92
, 141107
(2008
).8.
J. T.
Robinson
, L.
Chen
, and M.
Lipson
, Opt. Express
16
, 4296
(2008
).9.
A. H. C.
Ren
, F.
Vollmer
, and S.
Arnold
, Opt. Express
15
, 17410
(2007
).10.
F.
Vollmer
, S.
Arnold
, and D.
Keng
, Proc. Natl. Acad. Sci. U.S.A.
105
, 20701
(2008
).11.
A. M.
Armani
, R. P.
Kulkarni
, S. E.
Fraser
, R. C.
Flagan
, and K. J.
Vahala
, Science
317
, 783
(2007
).12.
M.
Han
and A.
Wang
, Opt. Lett.
32
, 1800
(2007
).13.
L.
He
, Y. -F.
Xiao
, C. -H.
Dong
, J. -G.
Zhu
, V.
Gaddam
, and L.
Yang
, Appl. Phys. Lett.
93
, 201102
(2008
).14.
A.
Mazzei
, S.
Götzinger
, L.
de S. Menezes
, G.
Zumofen
, O.
Benson
, and V.
Sandoghdar
, Phys. Rev. Lett.
99
, 173603
(2007
).15.
K. R.
Hiremath
and V. N.
Astratov
, Opt. Express
16
, 5421
(2008
).16.
T. J.
Kippenberg
, A. L.
Tchebotareva
, J.
Kalkman
, A.
Polman
, and K. J.
Vahala
, Phys. Rev. Lett.
103
, 027406
(2009
).17.
B.
Koch
, Y.
Yi
, J. -Y.
Zhang
, S.
Znameroski
, and T.
Smith
, Appl. Phys. Lett.
95
, 201111
(2009
).18.
L.
Deych
and J.
Rubin
, Phys. Rev. A
80
, 061805
(R) (2009
).19.
I.
Teraoka
and S.
Arnold
, J. Opt. Soc. Am. B
26
, 1321
(2009
).20.
J.
Zhu
, S. K.
Ozdemir
, Y. -F.
Xiao
, L.
Li
, L.
He
, D. -R.
Chen
, and L.
Yang
, Nat. Photonics
4
, 46
(2010
).21.
J.
Knittel
, T. G.
McRae
, K. H.
Lee
, and W. P.
Bowen
, Appl. Phys. Lett.
97
, 123704
(2010
).22.
M.
Noto
, D.
Keng
, I.
Teraoka
, and S.
Arnold
, Biophys. J.
92
, 4466
(2007
).23.
B.
Min
, L.
Yang
, and K.
Vahala
, Phys. Rev. A
76
, 013823
(2007
).24.
J.
Topolancik
and F.
Vollmer
, Biophys. J.
92
, 2223
(2007
).© 2010 American Institute of Physics.
2010
American Institute of Physics
You do not currently have access to this content.
